Results 11 to 20 of about 1,966 (247)

Quantitative Analysis of Clot Deposition on Extracorporeal Life Support Membrane Oxygenators Using Digital and Scanning Electron Microscopy Imaging Techniques

Bio-Protocol, 2023
Device-induced thrombosis remains a major complication of extracorporeal life support (ECLS). To more thoroughly understand how blood components interact with the artificial surfaces of ECLS circuit components, assessment of clot deposition on these ...
Yanyi Zang, Teryn Roberts, George Harea, Brendan Beely, Leonardo Olivera Perez, Sreedevi Ande, Maria Batchinsky, Ji Lee, Marianne Thrailkill, Melissa Reynolds, Andriy Batchinsky   +10 more
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A Clinical‐Scale Microfluidic Respiratory Assist Device with 3D Branching Vascular Networks

Advanced Science, 2023
Recent global events such as COVID‐19 pandemic amid rising rates of chronic lung diseases highlight the need for safer, simpler, and more available treatments for respiratory failure, with increasing interest in extracorporeal membrane oxygenation (ECMO).
Brett C. Isenberg, Else M. Vedula, Jose Santos, Diana J. Lewis, Teryn R. Roberts, George Harea, David Sutherland, Beau Landis, Samuel Blumenstiel, Joseph Urban, Daniel Lang, Bryan Teece, WeiXuan Lai, Rose Keating, Diana Chiang, Andriy I. Batchinsky, Jeffrey T. Borenstein   +16 more
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Development of a new low-volume oxygenator and creation of a hydrodynamic test bench for ex vivo lung perfusion in small animals

Вестник трансплантологии и искусственных органов, 2023
Small animal models are widely used in basic research. However, experimental hydrodynamic test benches, which include extracorporeal circuits, often have limitations associated with the size and filling volume of equipment.
O. Yu. Esipova, V. K. Bogdanov, A. S. Esipov, A. P. Kuleshov, A. S. Buchnev, E. A. Volkova, A. A. Drobyshev, N. V. Grudinin   +7 more
doaj   +1 more source

Water as a Blood Model for Determination of CO₂ Removal Performance of Membrane Oxygenators

Membranes, 2021
CO2 removal via membrane oxygenators has become an important and reliable clinical technique. Nevertheless, oxygenators must be further optimized to increase CO2 removal performance and to reduce severe side effects.
Benjamin Lukitsch, Raffael Koller, Paul Ecker, Martin Elenkov, Christoph Janeczek, Markus Pekovits, Bahram Haddadi, Christian Jordan, Margit Gfoehler, Michael Harasek   +9 more
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Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Research and Practice in Thrombosis and Haemostasis, 2020
Background The contact factor XII (FXII) activates upon contact with a variety of charged surfaces. Activated FXII (FXIIa) activates factor XI, which activates factor IX, resulting in thrombin generation, platelet activation, and fibrin formation.
Michael Wallisch, Christina U. Lorentz, Hari H. S. Lakshmanan, Jennifer Johnson, Marschelle R. Carris, Cristina Puy, David Gailani, Monica T. Hinds, Owen J. T. McCarty, András Gruber, Erik I. Tucker   +10 more
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Evaluation of Different Control Algorithms for Carbon Dioxide Removal with Membrane Oxygenators

Applied Sciences, 2022
Membrane oxygenators are devices that benefit from automatic control. This is especially true for implantable membrane oxygenators—a class of wearable rehabilitation devices that show high potential for fast recovery after lung injury.
Martin Elenkov, Benjamin Lukitsch, Paul Ecker, Christoph Janeczek, Michael Harasek, Margit Gföhler   +5 more
doaj   +1 more source

Oxygen Profiles in Membranes [PDF]

Biophysical Journal, 2006
Transmembrane profiles of molecular oxygen in lipid bilayers are not only significant for membrane physiology and pathology, but also are essential to the determination of membrane protein structure by site-directed spin labeling. Oxygen profiles obtained with spin-labeled lipid chains have a Boltzmann sigmoidal dependence on the depth into each lipid ...
Marsh, D., Dzikovski, B., Livshits, V.
openaire   +3 more sources

Microstructured Hollow Fiber Membranes: Potential Fiber Shapes for Extracorporeal Membrane Oxygenators

Membranes, 2021
Extracorporeal membrane oxygenators are essential medical devices for the treatment of patients with respiratory failure. A promising approach to improve oxygenator performance is the use of microstructured hollow fiber membranes that increase the ...
Paul Ecker, Markus Pekovits, Tsvetan Yorov, Bahram Haddadi, Benjamin Lukitsch, Martin Elenkov, Christoph Janeczek, Christian Jordan, Margit Gfoehler, Michael Harasek   +9 more
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Extracorporeal membrane oxygenation

Current Opinion in Critical Care, 2005
Extracorporeal membrane oxygenation (ECMO) has become a more or less accepted standard in the algorithm of advanced acute respiratory distress syndrome therapy in adult patients when all other treatment options have failed. This article reviews the current status of ECMO therapy with particular focus on new technical developments and their potential ...
Frank, Mielck, Michael, Quintel
openaire   +3 more sources

Suitable CO₂ Solubility Models for Determination of the CO₂ Removal Performance of Oxygenators

Bioengineering, 2021
CO2 removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO2 removal rate is necessary.
Benjamin Lukitsch, Paul Ecker, Martin Elenkov, Christoph Janeczek, Christian Jordan, Claus G. Krenn, Roman Ullrich, Margit Gfoehler, Michael Harasek   +8 more
doaj   +1 more source