Results 21 to 30 of about 63,350 (232)

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

Nature Communications
Neuronal TDP-43 aggregates are a hallmark ALS pathology. The integrated stress response (ISR) occurs downstream of TDP-43 pathology and may promote neurodegeneration.
Brittany N. Flores, Seungyoon B. Yu, Isaac V. Cohen, Melania H. Fanok, Wei Luan, Romeo D. Maciuca, Linus D. Sun, Richard M. Tsai, Maurits Vissers, Lars Smits, Tommy M. Bunte, Anna Bakardjiev, Srijana Balasundar, Meredith E. K. Calvert, Marcus Y. Chin, Sarah K. Dobbins, William E. Dowdle, Meng Fang, Jules A. A. C. Heuberger, Connie L. Ha, Fen Huang, Takashi Miyamoto, Maksim Osipov, Lidia Madrid San Martin, Katie Saund, David Tatarakis, Anthony Q. Vu, Chenling Xiong, Gene W. Yeo, Geert Jan Groeneveld, Leonard H. van den Berg, Shyeilla Dhuria, Anthony A. Estrada, Danna Jennings, Thomas Sandmann, Carole Ho, Kimberly Scearce-Levie, Ernie Yulyaningsih, Adam K. Walker, Gilbert Di Paolo, Lesley A. Kane, Matthew D. Troyer, Joseph W. Lewcock   +42 more
doaj   +1 more source

An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

Antibodies
Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies.
Yinghui Rong, I-Ling Chen, Lance Larrabee, Manali S. Sawant, Germaine Fuh, Patrick Koenig   +5 more
doaj   +1 more source

Purification and Identification of Peptides from Oyster (Crassostrea hongkongensis) Protein Enzymatic Hydrolysates and Their Anti-Skin Photoaging Effects on UVB-Irradiated HaCaT Cells

Marine Drugs, 2022
This study aimed to purify and identify antiphotoaging peptides from oyster (Crassostrea hongkongensis) protein enzymatic hydrolysates (OPEH) and to investigate the possible mechanism underlying its antiphotoaging effect.
Zhilan Peng, Jialong Gao, Weimin Su, Wenhong Cao, Guoping Zhu, Xiaoming Qin, Chaohua Zhang, Yi Qi   +7 more
doaj   +1 more source

The Fish and Oyster Laws of Texas [PDF]

, 1922
Text of laws governing fishing and oyster culture, as well as regulation by the Game, Fish, and Oyster Commission.
Texas. Game, Fish, and Oyster Commission.
core  

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Metagenomes and metagenome-assembled genomes from tidal lagoons at a New York City waterfront park [PDF]

PeerJ
New York City parks serve as potential sites of both social and physical climate resilience, but relatively little is known about how microbial organisms and processes contribute to the functioning of these deeply human-impacted ecosystems. We report the
Sally Kong, Eliana Abrams, Yehuda Binik, Christina Cappelli, Mathew Chu, Taiyo Cornett, Isayah Culbertson, Epifania Garcia, Jada Henry, Kristy Lam, D.B. Lampman, Grace Morenko, Illusion Rivera, Tanasia Swift, Isabella Torres, Rayven Velez, Elliot Waxman, Serena Wessely, Anthony Yuen, Casey K. Lardner, J.L. Weissman   +20 more
doaj   +2 more sources

Impact of Land Reclamation on Coastal Water in a Semi-Enclosed Bay

Remote Sensing, 2023
Land reclamation has a profound impact on coastal environments. On the Chinese coast, the new Xiang’an International Airport has been built on newly reclaimed land.
Min-cheng Tu, Yu-chieh Huang
doaj   +1 more source

The Fish and Oyster Laws of Texas [PDF]

, 1923
Text of laws governing fishing and oyster culture, as well as regulation by the Game, Fish, and Oyster Commission.
Texas. Game, Fish, and Oyster Commission.
core  

The Power of Unity: Collective Action and Smallholder Agricultural Performance in West Africa

Agribusiness, EarlyView.
ABSTRACT We analyze the impact of collective action through farmer‐based organizations (FBOs) on smallholders' farm performance and income inequality in Ghana, Benin, The Gambia, and Mali. We find that FBO membership increases cereal yield in Ghana and The Gambia, legume yield in Mali, ruminant numbers in Benin and The Gambia, and total farm income in ...
Emmanuel Donkor, Bright Owusu Asante, David Boansi, Victor Owusu   +3 more
wiley   +1 more source

The Fish and Oyster Laws of Texas [PDF]

, 1921
Text of laws governing fishing and oyster culture, as well as regulation by the Game, Fish, and Oyster Commission.
Texas. Game, Fish, and Oyster Commission.
core