Results 41 to 50 of about 216,032 (289)

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

open access: yesNature Communications
Neuronal TDP-43 aggregates are a hallmark ALS pathology. The integrated stress response (ISR) occurs downstream of TDP-43 pathology and may promote neurodegeneration.
Brittany N. Flores   +42 more
doaj   +1 more source

Bioaccessibility and Intestinal Transport of Deltamethrin in Pacific Oyster (Magallana Gigas) Using Simulated Digestion/NCM460 Cell Models

open access: yesFrontiers in Nutrition, 2021
Deltamethrin (DEL) can be introduced into the food chain through bioaccumulation in Pacific oysters, and then potentially threaten human health. The objective of this study was to investigate the bioaccessibility of DEL in oysters with different cooking ...
Yadan Jiao   +6 more
doaj   +1 more source

Oyster Bed Mapping in the Great Bay Estuary, 2012-2013 [PDF]

open access: yes, 2013
Six major oyster beds (reefs) in New Hampshire are mapped periodically to assess wild oyster populations in the Great Bay Estuary. Data on the spatial extent of the beds are combined with density and other measures to estimate the abundances of live ...
Grizzle, Raymond E., Ward, Krystin M.
core   +2 more sources

Mesopelagic Fish as a Promising New Source of Omega‐3 Fatty Acids in Comparison With Australian Commercial Seafood

open access: yesJournal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Global dietary guidelines consistently recommend regular seafood consumption to support adequate omega‐3 long‐chain (≥ C20) polyunsaturated fatty acid (n‐3 LC‐PUFA) intake. Most international health authorities advise two servings of seafood per week, including at least one serve of oily fish, to achieve approximately 500 mg/day of combined ...
Bowen Zhang   +3 more
wiley   +1 more source

An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

open access: yesAntibodies
Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies.
Yinghui Rong   +5 more
doaj   +1 more source

Pilot investigation of remote sensing for intertidal oyster mapping in coastal South Carolina: a methods comparison [PDF]

open access: yes, 2003
South Carolina’s oyster reefs are a major component of the coastal landscape. Eastern oysters Crassostrea virginica are an important economic resource to the state and serve many essential functions in the environment, including water filtration, creek ...

core  

Gleaning the Rocky Shore? 2500 Years of Coastal Resource Use at Red Bluff 1, GunaiKurnai Country, SE Australia

open access: yesArchaeology in Oceania, EarlyView.
ABSTRACT Shell middens in Gippsland along the eastern half of Victoria's coastline have usually been characterised as small, short‐duration camp sites with relatively low shell densities and low taxonomic diversity. Here we present new excavation results from a dense, high‐diversity site at Red Bluff near the eastern end of GunaiKurnai Country, a ...
Patrick Faulkner   +17 more
wiley   +1 more source

Physical and Microstructure Properties of Oyster Mushroom-Soy Protein Meat Analog via Single-Screw Extrusion

open access: yesFoods, 2020
Single-screw extrusion of a fibrous-structured meat analog from soy proteins added with low-grade oyster mushroom was successful. Satisfactory extrudates were obtained at a barrel temperature of 140 °C, screw speed range of 100–160 rpm, and oyster ...
Mazween Mohamad Mazlan   +6 more
semanticscholar   +1 more source

Introduction, establishment and expansion of the Pacific oyster Crassostrea gigas in the Oosterschelde (SW Netherlands) [PDF]

open access: yes
The Pacific oyster Crassostrea gigas was first introduced as an exotic species by oyster farmers in 1964 in the Oosterschelde estuary (SW Netherlands). The initial phase is not well documented but first natural spatfall was recorded in 1975.
Kater, B.J.   +2 more
core   +6 more sources

A practical method for determining the rate of covalent modification of fragments and leads

open access: yesNature Communications
The clinical success of covalent drugs such as sotorasib has renewed interest in covalency for rational drug design. The most rigorous potency metric for covalent modifiers is the second-order rate constant k inact /K I.
Janice Jeon   +5 more
doaj   +1 more source

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