Results 171 to 180 of about 15,888 (201)

Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist

Nature, 1995
The increase in the number of reports of abnormalities in male sex development in wildlife and humans coincided with the introduction of 'oestrogenic' chemicals such as DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) into the environment. Although these phenotypic alterations are thought to be mediated by the oestrogen receptor, they are also ...
W R, Kelce, C R, Stone, S C, Laws, L E, Gray, J A, Kemppainen, E M, Wilson   +5 more
openaire   +2 more sources

p,p′-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells

Toxicology, 2008
p,p'-Dichlorodiphenoxydichloroethylene (p,p'-DDE), the major metabolite of dichlorodiphenoxytrichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant. However, the mechanism underlying male reproductive toxicity of p,p'-DDE remains limited.
Yang, Song, Xianmin, Liang, Yafei, Hu, Yinan, Wang, Haige, Yu, Kedi, Yang   +5 more
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Transplacental and Lactational Transfer of p,p′-DDE in Sprague–Dawley Rats

Toxicology and Applied Pharmacology, 1999
p,p'-DDE (hereafter DDE), a persistent metabolite of p,p'-DDT, is a widespread environmental contaminant that can induce antiandrogenic developmental effects in rats. Quantitative measurements of the transfer of DDE from pregnant or lactating dams to the fetus or suckling neonate were performed, and physiologically based pharmacokinetic (PBPK) models ...
L, You, E, Gazi, S, Archibeque-Engle, M, Casanova, R B, Conolly, H A, Heck   +5 more
openaire   +2 more sources

Induction of hepatic aromatase by p,p′-DDE in adult male rats

Molecular and Cellular Endocrinology, 2001
1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE, DDE) is a stable metabolite of the pesticide DDT and a persistent environmental pollutant. Earlier reports have demonstrated that DDE is an endocrine-active compound capable of affecting early-stage sexual differentiation in male rats.
L, You, M, Sar, E, Bartolucci, S, Ploch, M, Whitt   +4 more
openaire   +2 more sources

Levels of p , p ′-DDE in Liver of Predatory Birds from Calabria, Italy

Bulletin of Environmental Contamination and Toxicology, 2002
In the present study, the levels of OCs in the liver of predatory birds were evaluated. Liver samples were collected from 80 birds (9 different species) found dead or dying in the territory of Calabria region of Southern Italy from 1993 to 1997. Collected data were compared to data already available regarding the OCs contamination in predatory birds ...
DE LIGUORO, MARCO, AMORENA M, NASO B, DONATO A, LUCISANO A.   +4 more
openaire   +4 more sources

Association between environmental exposure to p, p′-DDE and lindane and semen quality

Environmental Science and Pollution Research, 2014
Scientific concern exists about the toxic effect of dichlorodiphenyldichloroethylene (p, p'-DDE) and lindane on male infertility, and the mechanism underlying male reproductive toxicity of this pesticide remains unanswered. We investigated not only the possible association between the chlorinated pesticide levels and semen quality in nonoccupationally ...
Niraj, Pant, M, Shukla, A D, Upadhyay, P K, Chaturvedi, D K, Saxena, Y K, Gupta   +5 more
openaire   +2 more sources

Influence of plant–earthworm interactions on SOM chemistry and p,p′-DDE bioaccumulation

Chemosphere, 2011
Laboratory experiments assessed how bioaccumulation of weathered p,p'-DDE from soil and humic acid (HA) chemistry are affected by interactions between the plants Cucurbita pepo ssp. pepo and ssp. ovifera and the earthworms Eisenia fetida, Lumbricus terrestris, and Apporectodea caliginosa. Total organochlorine phytoextraction by ssp.
Jason W, Kelsey, Ilya B, Slizovskiy, Michael C, Petriello, Kelly L, Butler   +3 more
openaire   +2 more sources

Mechanisms of p,p′-DDE-induced apoptosis in human peripheral blood mononuclear cells

Toxicology in Vitro, 2009
p,p'-Dichlorodiphenyldichloroethylene (DDE), the most stable metabolite of organochlorine insecticide p,p'-dichlorodiphenyltrichloroethane (DDT), has been detected in human populations living in malaria-endemic areas of México where this insecticide was used.
Jorge A, Alegría-Torres, Fernando, Díaz-Barriga, A Jay, Gandolfi, Iván N, Pérez-Maldonado   +3 more
openaire   +2 more sources

p,p′-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes

Fish & Shellfish Immunology, 2005
p,p'-DDE, the main metabolite of DDT, is still detected in aquatic environments throughout the world. Here, the effects and mechanisms by which p,p'-DDE exposure might affect the immune system of chinook salmon (Oncorhynchus tshawytscha) was studied. Isolated salmon splenic and pronephric leukocytes were incubated with different concentrations of p,p ...
Ichiro, Misumi, Anthony T, Vella, Jo-Ann C, Leong, Teruyuki, Nakanishi, Carl B, Schreck   +4 more
openaire   +2 more sources

Transcriptome signatures of p,p´-DDE-induced liver damage in Mus spretus mice

Environmental Pollution, 2018
The use of DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane) in some countries, although regulated, is contributing to an increased worldwide risk of exposure to this organochlorine pesticide or its derivative p,p'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene].
Noelia Morales-Prieto, Julia Ruiz-Laguna, David Sheehan, Nieves Abril   +3 more
openaire   +2 more sources