Results 11 to 20 of about 10,413 (159)

Sex-Based Evaluation of Lipid Profile in Postoperative Adjuvant Mitotane Treatment for Adrenocortical Carcinoma

Biomedicines, 2022
Background: A wide interindividual variability in mitotane concentrations and treatment-related dyslipidemia have been reported. Here, we aimed to underline the sex-related differences in the lipid profile in patients that underwent radical surgery of ...
Sarah Allegra, Soraya Puglisi, Chiara Borin, Francesco Chiara, Vittoria Basile, Anna Calabrese, Giuseppe Reimondo, Silvia De Francia   +7 more
doaj   +1 more source

Excretion Rate and Accumulating Rate of p, p'-DDE in Beijing Resident during Consecutive Lactation

Yankuang ceshi, 2021
BACKGROUND Monitoring of p, p'-DDE in breast milk was a significant way to evaluate the p, p'-DDE accumulation level in human beings within a short-term and calculate daily intake for infants.
SONG Shu-ling, PAN Meng, MA Xiao-dong
doaj   +1 more source

Effects of p,p'-DDE on H19 DMR methylation and insulin secretion of INS-1 cells

环境与职业医学, 2022
BackgroundDiabetes is a major threat to public health across the world. Studies have shown that exposure to p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) is closely related to the occurrence of type 2 diabetes mellitus. However, the relevant molecular
Yanqiu ZONG, Huasen XIE, Xiaoqing LI, Lijun WANG, Lei YANG, Yang SONG   +5 more
doaj   +1 more source

Effects of o,p’-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line

Pharmaceuticals, 2022
In South Brazil, the incidence of pediatric adrenocortical carcinoma (ACC) is higher than in other regions and countries worldwide. The ACC treatment includes therapy with mitotane, the only adrenolytic drug approved by the FDA.
Camila Bach, Claudia Rita Corso, Alan de Almeida Veiga, Mariana Martins Paraizo, Lauro Mera de Souza   +4 more
doaj   +1 more source

Chronic DDE Exposure Modifies Mitochondrial Respiration during Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Mature Adipocytes

Biomolecules, 2021
The contribution of environmental pollutants to the obesity pandemic is still not yet fully recognized. Elucidating possible cellular and molecular mechanisms of their effects is of high importance.
Iva Kladnicka, Miroslava Cedikova, Jan Jedlicka, Michaela Kohoutova, Ludek Muller, Iveta Plavinova, Michaela Kripnerova, Monika Bludovska, Jitka Kuncova, Dana Mullerova   +9 more
doaj   +1 more source

Exposure to CB-153 and p,p'-DDE and male reproductive function [PDF]

Human Reproduction, 2004
During the last decades, there has been concern that exposure to endocrine disruptors, such as persistent organochlorine pollutants (POPs), may contribute to an impairment of male reproductive function. To investigate whether exposure to 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) affects semen
A, Rignell-Hydbom, L, Rylander, A, Giwercman, B A G, Jönsson, P, Nilsson-Ehle, L, Hagmar   +5 more
openaire   +2 more sources

Pesticide residue levels in surface water, using a passive sampler and in the sediment along the littoral zone of Lake Ziway at selected sites

SN Applied Sciences, 2022
Diaion® HP-20 resin passive samplers deployed in water and sediment samples collected from Lake Ziway were analyzed for 30 organochlorine, organophosphorus, carboxamide, and pyrethroid pesticide residues.
Mekuria Teshome Mergia, Ermias Deribe Weldemariam, Ole Martin Eklo, Girma Tilahun Yimer   +3 more
doaj   +1 more source

p, p'-Dichlorodiphenyldichloroethylene induces colorectal adenocarcinoma cell proliferation through oxidative stress. [PDF]

PLoS ONE, 2014
p, p'-Dichlorodiphenyldichloroethylene (DDE), the major metabolite of Dichlorodiphenyltrichloroethane (DDT), is an organochlorine pollutant and associated with cancer progression.
Li Song, Jianxin Liu, Xiaoting Jin, Zhuoyu Li, Meirong Zhao, Weiping Liu   +5 more
doaj   +1 more source

Identification of common genetic variants associated with serum concentrations of p, p′-DDE in non-occupational populations in eastern China

Environment International, 2021
Dichlorodiphenyldichloroethylene (DDE) is the major and most stable toxic metabolite of dichlorodiphenyltrichloroethane (DDT), a well-known organochlorine pesticide banned worldwide in the 1980s. However, it remains easy to detect in humans, and internal
Shushu Li, Wei Shao, Chao Wang, Li Wang, Rong Xia, Shen Yao, Mulong Du, Xiaoming Ji, Haiyan Chu, Zhengdong Zhang, Meilin Wang, Shou-Lin Wang   +11 more
doaj   +1 more source

Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice

Environmental Health, 2021
Background Exposure to the bioaccumulative pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) has been associated with increased risk of insulin resistance and obesity in humans and experimental ...
Annalise N. vonderEmbse, Sarah E. Elmore, Kyle B. Jackson, Beth A. Habecker, Katherine E. Manz, Kurt D. Pennell, Pamela J. Lein, Michele A. La Merrill   +7 more
doaj   +1 more source