Results 81 to 90 of about 461,399 (248)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Efecto del drenaje biliar preoperatorio en infecciones abdominales postoperatorias de pancreatoduodenectomias en el centro médico docente La Trinidad: análisis retrospectivo

Revista Científica CMDLT
El drenaje biliar preoperatorio se utiliza para aliviar la ictericia y mejorar la función hepática previo a cirugía, pero existe debate sobre la efectividad y relación con las complicaciones postoperatorias.
Dimas Valdemar Alviarez Rosales, Daniela Roa, Antonio Cardenas, Mauro Carretta   +3 more
doaj   +1 more source

“HALLAZGOS EN LAPAROTOMIA EXPLORATORIA EN PACIENTES ADULTOS CON TRAUMA ABDOMINAL EN EL HOSPITAL GENERAL DR. NICOLAS SAN JUAN 2007 A 2012.” [PDF]

, 2013
El trauma abdominal es la lesión que recibe este compartimento, ocasionada por fuerzas externas. El abdomen es la tercera región del organismo más frecuentemente lesionada en los traumatismos, y el trauma abdominal es la causa del 20% de las lesiones ...
Aguirre Benancio, Adriana Betzabet, Flores Morales, José Luis, Santana Maya, Ever Evelin   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

APLICACIÓN DE UN INSTRUMENTO PARA EVALUAR EL NIVEL DE CONOCIMIENTOS EN PACIENTES CON DIABETES MELLITUS TIPO 2 SOBRE SU ENFERMEDAD, ANTES Y DESPUÉS DE UNA ORIENTACIÓN NUTRICIONAL EN EL H.G.Z No. 71 DEL IMSS EN EL PERIODO FEBRERO- AGOSTO 2014 [PDF]

, 2015
La Diabetes es una enfermedad crónica que aparece cuando el páncreas no produce insulina suficiente o cuando el organismo no utiliza eficazmente la insulina que produce.
FLORES HERNÁNDEZ, LAURA, SÁNCHEZ PÉREZ, GUADALUPE MIRIAM   +1 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

El Síndrome Metabólico como factor de riesgo para el desarrollo de Diabetes Mellitus de Tipo 2 [PDF]

, 2015
El Síndrome Metabólico (SM), de gran prevalencia en la población mundial, se define como un conjunto de factores fisiológicos, bioquímicos, clínicos y metabólicos, que se encuentran interconectados (hipertensión, obesidad abdominal, dislipemia ...
Álvarez Rodríguez, Virginia
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source