Results 151 to 160 of about 14,988,203 (289)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nitrogen Phase Diagram at High P–T Conditions by the T‑USPEX Method

It is known that under normal conditions nitrogen exists in a gaseous state and makes up most of the Earth’s atmosphere. However, under high P–T conditions, nitrogen can transform into a condensed state, being a nonmolecular polymeric structure.
I. A. Kruglov (14761144), Y. V. Propad (14809111), L. A. Bereznikova (14809108)   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Existence of global solutions for systems of second-order functional-differential equations with p-Laplacian

Electronic Journal of Differential Equations, 2008
We find sufficient conditions for the existence of global solutions for the systems of functional-differential equations $$ ig(A(t)Phi_p(y')ig)' + B(t)g(y', y'_t) + R(t)f(y, y_t) = e(t), $$ where $Phi_p(u) = (|u_1|^{p-1}u_1, dots, |u_n|^{p-1}u_n)^T$
Miroslav Bartusek, Milan Medved
doaj  

High-P metamorphism in submarine volcanic rocks of Espasante (II): P-T conditions and reaction evolution

, 2016
El bloque tectónico de metavulcanitas de la Mélange de Somozas se caracteriza por registrar un evento de alta-P ocurrido durante su subducción. Este evento se refleja únicamente en la matriz hialoclastítica, que desarrolló una mineralogía compleja ...
Díez Fernández, Rubén, Garcia Casco, Antonio, Arenas Martín, Ricardo, Novo Fernández, Irene   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Determination of the P-T conditions and depths of magma storage zones for two distinct quaternary lava flows in the Southeast of Mount Ağrı (Eastern Anatolia, Turkey). [PDF]

PLoS One
Dogan-Kulahci GD.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ca₃[C₂O₅]₂[CO₃] is a pyrocarbonate which can be formed at p, T-conditions prevalent in the Earth's transition zone. [PDF]

Commun Chem
Spahr D, Bayarjargal L, Bykov M, Brüning L, Jurzick PL, Wang Y, Milman V, Refson K, Mezouar M, Winkler B.   +9 more
europepmc   +1 more source