Results 141 to 150 of about 40,513,033 (232)

P-T-t-deformation framework of an accretionary prism, southern New England Orogen, eastern Australia: implications for blueschist exhumation and metamorphic switching

The Tia Complex is located in the southern New England Orogen of eastern Australia and provides a detailed record of the structural-metamorphic evolution of an ancient accretionary prism.
Robin Offler (21132722), G. Phillips (2999349), M. Hand (691266)   +2 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Physiological sub-typing of cold and freezing injury in <i>Triticum turgidum</i> subspecies with bioinformatic and expression characterization of glutathione reductase. [PDF]

PeerJ
Sipahi H, Kutlu I, Darwiche R.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Personal Papers (MS 80-0002)

, 1960
Letter from Harris L. Kempner to T. P. Davis congratulating him on being appointed Resident Vice-President of the First National Bank of New York in ...
Kempner, Harris Leon
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

LILRB4 Attenuates Ischemic Brain Injury by Inhibiting Microglial Necroptosis via a RIPK3-Dependent Mechanism. [PDF]

Glia
Hu J, Zhang M, Liu P, Chen Y, Meng H, Xia S, Bao X, Xu Y, Chen Y.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Integrating Meta-Analysis Into a Specific Study (InMASS) for Estimating the Target-Population Average Treatment Effect. [PDF]

Biom J
Hanada K, Kojima M.
europepmc   +1 more source

Sense-T: Sensor smart irrigation

, 2017
The Sense-T Sensor-Smart Irrigation app predicts daily soil-water in the infield spatial zones using FAO-56. The irrigation requirement is determined in each zone from the difference between the predicted soil-water and field capacity. Incorporation of a
McCarthy, Alison, Agustina, Lidya, Shippam, Ralph   +2 more
core