Results 91 to 100 of about 18,720,874 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Convergent Validity.

open access: yes, 2017
Convergent Validity.
Tamara Silio-García (3625691)   +11 more
core   +1 more source

Composite reliability and convergent validity.

open access: yes, 2023
Composite reliability and convergent validity.
Isha Garg (14608681)   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Composite reliability and convergent validity.

open access: yes, 2021
Composite reliability and convergent validity.
Syed Sohaib Zubair (11785527)   +2 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Convergent multiples of convergent operators

open access: yes, 1999
Let “X≫0” mean that “the bounded linear Hilbert-space operator X is selfadjoint, positive, and invertible”. We discuss the operators A which are known to be convergent (i.e. have spectral radius less than 1) because they all satisfy Stein's condition P−A∗
Bryan E. Cain, Cain, Bryan E.
core   +1 more source

Results of convergent factor loading.

open access: yes, 2022
Results of convergent factor loading.
Yongyi Chen (8261175)   +2 more
core   +1 more source

Rate of P-convergence over equivalence classes of double sequence spaces

open access: yesPositivity, 2011
This paper presents multidimensional characterizations of equivalence classes of double sequences. These characterizations will be analyzed by presenting theorems of the following type: If A is convergent preserving over \({\{x \in S^{\prime\prime}_{0} : x \;{\rm equivalent \; to}\; b\}}\) then there exists a \({b^{\prime} \in S^{\prime\prime}_{0 ...
Patterson, Richard F., Savas, Ekrem
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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