Results 261 to 270 of about 553,081 (302)
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Parasitology Today, 1994
The P-glycoprotein (Pgp), a member of a group of integral membrane proteins that contain the ATP-binding cassette, is widely represented in the animal kingdom. A family of Pgp homologues has recently been described in nematodes. Pgps have been implicated in drug resistance in Plasmodium and in other parasitic protozoa, so the interest of ...
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The P-glycoprotein (Pgp), a member of a group of integral membrane proteins that contain the ATP-binding cassette, is widely represented in the animal kingdom. A family of Pgp homologues has recently been described in nematodes. Pgps have been implicated in drug resistance in Plasmodium and in other parasitic protozoa, so the interest of ...
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P-glycoprotein in breast cancer
1989Resistance to cytotoxic chemotherapy is a major impediment to the successful treatment of breast cancer. Adjuvant chemotherapy, though given under theoretically optimal conditions of low tumor bulk [1], often fails to eradicate micrometastasis.
D E, Merkel, S A, Fuqua, W L, McGuire
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Cytokine Regulation of P-Glycoprotein
Drug Metabolism Reviews, 2003P-glycoprotein (Pgp) is a membrane bound transporter involved in the disposition of many endogenous compounds and xenobiotics. Alterations in Pgp expression and activity can significantly affect the disposition of Pgp substrates. Infection and inflammatory stimuli have also been shown to alter drug disposition.
Mary Peace, McRae +2 more
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Photoaffinity Labeling of P-Glycoprotein
Mini-Reviews in Medicinal Chemistry, 2005The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and ...
Michael, Peer +4 more
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P-glycoprotein in autoimmune diseases
Autoimmunity Reviews, 2004Multidrug resistance-1 (MDR-1) is characterized by overfunction of P-glycoprotein (P-gp), a pump molecule that decreases intracellular drug concentration by effluxing them from the intracellular space. Broad ranges of structurally unrelated compounds are transported by P-gp, including antineoplastic agents, HIV protease inhibitors, prednisone, gold ...
Yvonne, Richaud-Patin +3 more
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P-Glycoproteins and Multidrug Resistance
Annual Review of Pharmacology and Toxicology, 1996Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs both in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent efflux pump to remove various
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Bromocriptine Modulates P-Glycoprotein Function
Biochemical and Biophysical Research Communications, 1998The multidrug resistance (MDR)-associated P-glycoprotein (P-gp) is a membrane transporter which carries, at the expense of MgATP hydrolysis, many amphiphilic molecules, such as the MDR-related cytotoxic drugs vincristine and vinblastine, and the MDR-reversing agents verapamil and progesterone.
S, Orlowski +3 more
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Herbal Modulation of PâGlycoprotein
Drug Metabolism Reviews, 2004P-glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1 gene. It is responsible for the systemic disposition of numerous structurally and pharmacologically unrelated lipophilic and amphipathic drugs, carcinogens, toxins, and other xenobiotics in many organs, such as the intestine, liver, kidney, and brain.
Zhou, Shufeng +2 more
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The P-glycoprotein multidrug transporter
Essays in Biochemistry, 2011Pgp (P-glycoprotein) (ABCB1) is an ATP-powered efflux pump which can transport hundreds of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs, peptides and lipid-like compounds. This 170 kDa polypeptide plays a crucial physiological role in protecting tissues from toxic xenobiotics and endogenous metabolites, and also
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The multidrug resistance P-glycoprotein
Current Opinion in Cell Biology, 1993P-glycoprotein plays an important role in the resistance of cancers to chemotherapy. Thus, an understanding of the mechanism by which it functions, and its 'normal' physiological role, is of clinical relevance as well as intrinsic interest. Considerable progress towards this goal has been made in the last year or so.
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