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P-glycoprotein in autoimmune diseases
Autoimmunity Reviews, 2004Multidrug resistance-1 (MDR-1) is characterized by overfunction of P-glycoprotein (P-gp), a pump molecule that decreases intracellular drug concentration by effluxing them from the intracellular space. Broad ranges of structurally unrelated compounds are transported by P-gp, including antineoplastic agents, HIV protease inhibitors, prednisone, gold ...
Yvonne, Richaud-Patin +3 more
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The P-glycoprotein multidrug transporter
General Pharmacology: The Vascular System, 19961. P-glycoprotein (P-gp) is a transmembrane protein involved in ATP-dependent efflux of various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases intracellular drug concentrations and, thus, confers a multidrug resistance phenotype. 2.
O, Fardel, V, Lecureur, A, Guillouzo
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Photoaffinity Labeling of P-Glycoprotein
Mini-Reviews in Medicinal Chemistry, 2005The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and ...
Michael, Peer +4 more
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P-glycoprotein in breast cancer
1989Resistance to cytotoxic chemotherapy is a major impediment to the successful treatment of breast cancer. Adjuvant chemotherapy, though given under theoretically optimal conditions of low tumor bulk [1], often fails to eradicate micrometastasis.
D E, Merkel, S A, Fuqua, W L, McGuire
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P-Glycoproteins and Multidrug Resistance
Annual Review of Pharmacology and Toxicology, 1996Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs both in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent efflux pump to remove various
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A role of P-glycoprotein in neurology
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017On the basis of the analysis of literature data, the authors show a role of P-glycoprotein in the pathogenesis, pharmacotherapy and a prophylaxis of neurologic diseases (Alzheimer's disease, Parkinson's disease, epilepsy, stroke).
I V, Chernykh +3 more
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Cytokine Regulation of P-Glycoprotein
Drug Metabolism Reviews, 2003P-glycoprotein (Pgp) is a membrane bound transporter involved in the disposition of many endogenous compounds and xenobiotics. Alterations in Pgp expression and activity can significantly affect the disposition of Pgp substrates. Infection and inflammatory stimuli have also been shown to alter drug disposition.
Mary Peace, McRae +2 more
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The multidrug resistance P-glycoprotein
Current Opinion in Cell Biology, 1993P-glycoprotein plays an important role in the resistance of cancers to chemotherapy. Thus, an understanding of the mechanism by which it functions, and its 'normal' physiological role, is of clinical relevance as well as intrinsic interest. Considerable progress towards this goal has been made in the last year or so.
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P-Glycoprotein: To flip or not to flip?
Current Biology, 1994The phenotype of mice homozygous for mutations of the mdr2 gene suggests that the mdr2 protein, which is closely related to the multidrug resistance P-glycoprotein, has a role in phospholipid transport.
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Structure and function of P-glycoprotein
1989P-glycoprotein remains the best understood molecule that has been implicated in the multidrug resistance phenomenon. As I have attempted to show, our understanding of this molecule is still in its infancy, with many questions as yet unanswered. It is anticipated that the answers to these questions will contribute to our understanding of drug resistance,
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