Results 121 to 130 of about 19,039,568 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

G-matrices

, 2015
All G-matrices used in the analyses. There are two matrices for each comparison, with the naming convention STUDYNAME_E# for between-environment comparisons) or STUDYNAME_P# (for between-population ...
Wood, Corlett Wolfe, Corlett Wolfe Wood (3257946), Edmund D. Brodie III (142668), Brodie III, Edmund D.   +3 more
core   +1 more source

A class of totally positive P-matrices whose inverses are M-matrices

Applied Mathematics Letters, 2007
AbstractIn this work we introduce some technical conditions to prove that a P-matrix has an inverse M-matrix. We study a class of totally positive P-matrices whose inverses are M-matrices.
Maite Gassó, Juan R. Torregrosa
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Power-law deformation of wishart-laguerre ensembles of random matrices

, 2008
We introduce a one-parameter deformation of the Wishart-Laguerre or chiral ensembles of positive definite random matrices with Dyson index beta=1,2 and 4.
Akemann, G, Vivo, P., Pierpaolo Vivo, Vivo, P, Akemann, Gernot, Gernot Akemann   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Systems of mutually unbiased Hadamard matrices containing real and complex matrices

, 2013
We use combinatorial and Fourier analytic arguments to prove various non-existence results on systems of real and com- plex unbiased Hadamard matrices.
Matolcsi, Máté, Weiner, Mihály, Ruzsa, Z. Imre   +2 more
core  

Superstatistical generalisations of Wishart-Laguerre ensembles of random matrices

, 2008
Using Beck and Cohen's superstatistics, we introduce in a systematic way a family of generalized Wishart–Laguerre ensembles of random matrices with Dyson index β = 1, 2 and 4. The entries of the data matrix are Gaussian random variables whose variances η
Akemann, G, Vivo, P., Vivo, P, Abul-Magd, A. Y., Akemann, Gernot, Abul-Magd, AY   +5 more
core   +1 more source

Nonexpansive Matrices with Applications to Solutions of Linear Systems by Fixed Point Iterations

Fixed Point Theory and Applications, 2010
We characterize (i) matrices which are nonexpansive with respect to some matrix norms, and (ii) matrices whose average iterates approach zero or are bounded. Then we apply these results to iterative solutions of a system of linear equations.
Lim Teck-Cheong
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