Results 91 to 100 of about 3,958,691 (296)

Steklov problems for the p−Laplace operator involving Lq-norm

open access: yesMoroccan Journal of Pure and Applied Analysis, 2022
In this paper, we are concerned with the study of the spectrum for the nonlinear Steklov problem of the form {Δpu=|u|p-2uin Ω,|∇u|p-2∂u∂v=λ‖u‖q,∂Ωp-q|u|q-2uon ∂Ω,\left\{ {\matrix{{{\Delta _p}u = {{\left| u \right|}^{p - 2}}u} \hfill & {{\rm{in}}\,\Omega ,
Alaoui My Driss Morchid   +2 more
doaj   +1 more source

Noncritical String Field Theory for 2d Quantum Gravity Coupled to (p, q)-Conformal Fields [PDF]

open access: yesInternational Journal of Modern Physics A, 1997
We propose a noncritical string field theory for 2d quantum gravity coupled to (p, q) conformal fields. The Hamiltonian is described by the generators of the Wp algebra, and the Schwinger–Dyson equation is equivalent to a vacuum condition imposed on the generators of Wp algebra.
Ambjørn, Jan, Watabiki, Y.
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Massive and Massless Neutrinos on Unbalanced Seesaws

open access: yes, 2007
The observation of neutrino oscillations requires new physics beyond the standard model (SM). A SM-like gauge theory with p lepton families can be extended by introducing q heavy right-handed Majorana neutrinos but preserving its SU(2)_L x U(1)_Y gauge ...
Altarelli G   +7 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy