Results 31 to 40 of about 29,687,790 (256)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
On Sketching the q to p Norms [PDF]
, 2018 We initiate the study of data dimensionality reduction, or sketching, for the q -> p norms. Given an n x d matrix A, the q -> p norm, denoted |A |_{q -> p} = sup_{x in R^d \ 0} |Ax |_p / |x |_q, is a natural generalization of several matrix and vector ...
Krishnan, Aditya +2 more
core +1 more source
Implementation of p-q theory on unified power flow controller [PDF]
, 2014 The Flexible AC Transmission System (FACTS) became popular since it was introduced by Hingorani in the late 1988. It can be considered as the best solution to transfer higher energy without building a new transmission line. This research focuses on the
Hassan, Haryani
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Non-hyperbolic 3-manifolds and 3D field theories for 2D Virasoro minimal models
SciPost PhysicsUsing 3D-3D correspondence, we construct 3D dual bulk field theories for general Virasoro minimal models $M(P,Q)$. These theories correspond to Seifert fiber spaces $S^2 ((P,P-R),(Q,S),(3,1))$ with two integers $(R,S)$ satisfying $PS-QR =1$.
Dongmin Gang, Heesu Kang, Seongmin Kim
doaj +1 more source
Three-dimensional teleparallel Chern-Simons supergravity theory
European Physical Journal C: Particles and Fields, 2021 In this work we present a gauge-invariant three-dimensional teleparallel supergravity theory using the Chern-Simons formalism. The present construction is based on a supersymmetric extension of a particular deformation of the Poincaré algebra.
Ricardo Caroca +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Coleman–Weinberg potential in p-adic field theory
European Physical Journal C: Particles and Fields, 2020 In this paper, we study $$\lambda \phi ^4$$ λ ϕ 4 scalar field theory defined on the unramified extension of p-adic numbers $${\mathbb {Q}}_{p^n}$$ Q p n .
Dmitry S. Ageev +2 more
doaj +1 more source