Results 51 to 60 of about 29,687,790 (256)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Ultrahigh–Q Microtoroid On-Chip Resonators for Low Threshold Microlasers [PDF]
, 2006 Recently demonstrated silica toroidal microcavities, as on-chip resonant cavities, become one of the most promising laser resonators due to their exceptional ability to confine optical energy temporarily and spatially (high Q-factor and small mode volume)
Min, Bumki
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
The solution of some persistent $p : -q$ resonant center problems
Electronic Journal of Qualitative Theory of Differential Equations, 2018 The notion of $p:-q$ resonant center was introduced recently and studied by several authors. In this paper we generalize the notion of a persistent center to a persistent $p:-q $ resonant center and find conditions for existence of a persistent $p:-q ...
Maja Zulj +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Hardy spaces associated with some anisotropic mixed-norm Herz spaces and their applications
Open Mathematics, 2023 In this article, we introduce anisotropic mixed-norm Herz spaces K˙q→,a→α,p(Rn){\dot{K}}_{\overrightarrow{q},\overrightarrow{a}}^{\alpha ,p}\left({{\mathbb{R}}}^{n}) and Kq→,a→α,p(Rn){K}_{\overrightarrow{q},\overrightarrow{a}}^{\alpha ,p}\left({{\mathbb ...
Zhao Yichun, Zhou Jiang
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Constraints of instantaneous reactive power p-q theory
, 2014 The instantaneous reactive power (IRP) p-q theory can be acknowledged as the first concept that provided fundamentals for switching compensator control and very often such a control is satisfactory.
Czarnecki, Leszek S.
core +1 more source