Results 71 to 80 of about 1,752,237 (247)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Finite groups with many p-regular conjugacy classes

Journal of Algebra
Let $G$ be a finite group and let $p$ be a prime. In this paper, we study the structure of finite groups with a large number of $p$-regular conjugacy classes or, equivalently, a large number of irreducible $p$-modular representations. We prove sharp lower bounds for this number in terms of $p$ and the $p'$-part of the order of $G$ which ensure that $G$
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Assessment of postural stability of 14-year-old girls training volleyball

Baltic Journal of Health and Physical Activity
Introduction: Measurements of postural stability are carried out for the prevention of injuries and for rehabilitation of athletes who have sustained traumatic injuries. The aim of the study was to assess postural stability measured in static and dynamic
Robert WALASZEK, Wiesław CHWAŁA, Katarzyna BURDACKA, Marcin BURDACKI, Paweł KUROWSKI   +4 more
doaj   +1 more source

$H^{s,p}$ regularity theory for a class of nonlocal elliptic equations

, 2019
28 pages.
openaire   +2 more sources

On p-parts of Brauer character degrees and p-regular conjugacy class sizes

, 2018
Let $G$ be a finite group, $p$ a prime, and $IBr_p(G)$ the set of irreducible $p$-Brauer characters of $G$. Let $\bar e_p(G)$ be the largest integer such that $p^{\bar e_p(G)}$ divides $ (1)$ for some $ \in IBr_p(G)$. We show that $|G:O_p(G)|_p \leq p^{k \bar e_p(G)}$ for an explicitly given constant $k$.
Bessenrodt, Christine, Yang, Yong
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Inclusão de alunos com necessidades educativas especiais na escola de ensino regular

Eventos Pedagógicos, 2016
O artigo discorre sobre a inclusão do aluno com necessidades educativas especiais na escola de ensino regular. A pesquisa, de abordagem qualitativa, teve como instrumento de coleta de dados entrevistas semiestruturadas com quatro professores.
Fernanda Aparecida Viana Ledesman
doaj