Results 261 to 270 of about 18,638,167 (297)

PSGL-1 decorated with sialyl Lewis^a/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. [PDF]

Sci Rep
O'Dwyer M, Kirkham-McCarthy L, Cerreto M, Foà R, Natoni A.   +4 more
europepmc   +1 more source

Immunoexpression of aortic endothelial P-selectin and serum apolipoprotein A-1 levels after administration of arabica (Coffea arabica) and robusta (Coffea canephora) coffee bean extracts: In vivo study in atherosclerosis rat model. [PDF]

Narra J
Ekawati W, Heriansyah T, Kamarlis RK, Purnawarman A, Sofyan H, Enitan SS.   +5 more
europepmc   +1 more source

Azab AK, Quang P, Azab F, et al. P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment. Blood. 2012;119(6):1468-1478.

Blood
europepmc   +1 more source

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Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs).
Tatyana Novoyatleva, B. Kojonazarov, A. Owczarek, Swathi Veeroju, Nabham Rai, I. Henneke, M. Böhm, F. Grimminger, H. Ghofrani, W. Seeger, N. Weissmann, R. Schermuly   +11 more
semanticscholar   +1 more source

Uncharged P-selectin blockers

Glycoconjugate Journal, 2003
The blocking potency of P- and L-selectin was studied for certain small molecule mannosides and their polyacrylamide (PAA, 30 kDa) conjugates in comparison to SiaLe(x) and fucoidan. Two experimental systems were used: (1) solid phase static assay based on recombinant selectins, and (2) P-selectin dependent rat peritoneal inflammation. betaMan-SC6H4NO2-
Pochechueva, T.V., Galanina, O.E., Ushakova, N.A., Preobrazhenskaya, M.E., Sablina, M.A., Nifantiev, N.E., Tsvetkov, Y.V., Vozney, Y.V., Imberty, A., Bovin, N.V.   +9 more
openaire   +2 more sources

P-selectin in arterial thrombosis

Zeitschrift f�r Kardiologie, 2004
P-selectin is a transmembrane protein present in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, it is rapidly translocated to the cell surface. P-selectin expression in platelets has been shown to be elevated in disorders associated with arterial thrombosis such as coronary artery disease, acute
M, Merten, P, Thiagarajan
openaire   +2 more sources

P-Selectin Antagonism in Inflammatory Disease

Current Pharmaceutical Design, 2010
Inflammation plays a fundamental role in many chronic diseases, including atherosclerosis associated cardiovascular disease. Adhesion of immune cells plays a critical role in the inflammatory response and indeed the pathophysiology of inflammatory related diseases.
Kevin J, Woollard, Jaye, Chin-Dusting
openaire   +2 more sources

P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Knowledge concerning the neurobiological importance of platelets in Alzheimer's disease (AD) is sparse. P-selectin, which is located together with β-amyloid precursor proteins in platelet α-granules, is also found in endothelial cells. Upon activation, P-selectin is relocated to cell surfaces where it acts as a receptor.
P. Järemo, M. Milovanovic, C. Buller, S. Nilsson, B. Winblad   +4 more
semanticscholar   +3 more sources

Targeting P-selectin in acute pancreatitis

Expert Opinion on Therapeutic Targets, 2010
Acute pancreatitis (AP) is a multifactorial disorder not fully understood yet. In particular, the pathogenetic pathways promoting a severe life-threatening course of AP are the subject of ongoing investigations. P-selectin has been shown to play a central role in the complex pathophysiology in AP as well as various other inflammatory conditions.P ...
Thilo, Hackert, Markus W, Büchler, Jens, Werner   +2 more
openaire   +2 more sources