Results 271 to 280 of about 18,638,167 (297)

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Blood, 2000
Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin– dependent rolling in ...
K E, Norman, A G, Katopodis, G, Thoma, F, Kolbinger, A E, Hicks, M J, Cotter, A G, Pockley, P G, Hellewell   +7 more
openaire   +2 more sources

Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G

Blood, 2001
In the inflammatory response, leukocyte rolling before adhesion and transmigration through the blood vessel wall is mediated by specific cell surface adhesion receptors. Neutrophil rolling involves the interaction of P-selectin expressed on activated endothelium and its counter-receptor on neutrophils, P-selectin glycoprotein ligand-1 (PSGL-1).
Gardiner, Elizabeth E., De Luca, Mariagrazia, McNally, Tracy, Michelson, Alan D., Andrews, Robert K., Berndt, Michael C.   +5 more
openaire   +3 more sources

Platelet surface p‐selectin, platelet–granulocyte heterotypic aggregates, and plasma‐soluble p‐selectin during plateletpheresis

Transfusion, 1999
BACKGROUND: Plateletpheresis components have been shown to contain p‐selectin‐positive platelets after collection and storage. P‐selectin mediates binding of activated platelets to granulocytes and monocytes. This study was undertaken to assess platelet activation, granulocyte activation, platelet–granulocyte heterotypic aggregate formation, and the ...
Barnard, Marc R., Macgregor, Hollace, Mercier, R., Ragno, G., Pivacek, L. E., Hechtman, Herbert B., Michelson, Alan D., Valeri, C. Robert   +7 more
openaire   +3 more sources

Interaction between Soluble P-Selectin and Soluble P-Selectin Glycoprotein Ligand 1:  Equilibrium Binding Analysis

Biochemistry, 1998
Leukocyte rolling in the vasculature is mediated by the interaction of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1). Since cell-cell interaction mediated by P-selectin and PSGL-1 is cooperative and complex, we have developed a model system to examine the binding of P-selectin to PSGL-1 in a soluble system.
K, Croce, S J, Freedman, B C, Furie, B, Furie   +3 more
openaire   +2 more sources

Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke

Thrombosis and Haemostasis, 2004
SummaryThe pathophysiology of ischaemic stroke involves the platelet. In this study, we hypothesised that abnormalities in platelet morphology, as well as soluble (sPsel) and total platelet P-selectin (pPsel) levels would be present in patients presenting with an acute ischaemic stroke, and that these changes would improve at ≥ 3 months’ follow-up.
Sunil K, Nadar, Gregory Y H, Lip, Andrew D, Blann   +2 more
openaire   +2 more sources

[Expression and identification of recombinant P-selectin and P-selectin glycoprotein ligand-1].

Sheng li xue bao : [Acta physiologica Sinica], 2015
P-selectin, one of the membrane proteins, expresses on platelet and endothelia and interacts with P-selectin glycoprotein ligand-1 (PSGL-1) on leukocyte membrane. This interaction mediates leukocytes rolling on endothelial membrane and then induces leukocyte recruitment to the site of infection or tissue injury. In the present study, we constructed the
Xin-Hui, Pei, Zhi-Xin, Lin, Jian-Guo, Geng   +2 more
openaire   +1 more source

Soluble P-selectin in Diabetes

Thrombosis and Haemostasis, 1999
Jilma, B., Fijnheer, R., Blann, A.D.
openaire   +2 more sources

Soluble P-selectin

Inflammatory Bowel Diseases, 2008
M Ku, J Rivera-Nieves
openaire   +1 more source

P-selectin

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

P-Selectin and Its Ligands

2012
When a blood vessel is injured, control of bleeding starts with the rapid adhesion of circulating platelets to the site of damage. Within seconds, the adhered platelets are activated, secrete the contents of storage organelles, spread out over the damaged area and recruit more platelets to the developing thrombus.
openaire   +1 more source