Crystal structure determination and thermal behavior upon melting of p -synephrine [PDF]
The crystal structure of p-synephrine was solved from a high-resolution X-ray powder diffraction pattern optimized by energy-minimization calculations using the Dreiding force field. The title compound crystallizes in a monoclinic system (space group P2 1 /c, Z = 4, with a = 8.8504(11) A, b = 12.1166(15) A, c = 9.7820(11) A,  = 122.551(2) • , V = 884 ...
Rosa, Frédéric +3 more
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Gilbert R Kaats,1 Robert B Leckie,2 Nate Mrvichin,1 Sidney J Stohs3 1Integrative Health Technologies, Inc., 2R.B. Leckie Research Consultants, San Antonio, TX, 3Creighton University Medical Center, Omaha, NE, USA Abstract: Using a placebo-controlled ...
Kaats GR +3 more
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A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. [PDF]
Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p-synephrine are widely assumed to be similar to those of ephedrine, m-synephrine (phenylephrine), and endogenous amine ...
Stohs SJ, Preuss HG, Shara M.
europepmc +5 more sources
Dietary supplements containing Citrus aurantium or p-synephrine remain very popular in Europe and the United States of America (USA). They are primarily sold as weight loss enhancers, although their efficacy and the safety are still under scrutiny.
Celine Vanhee +6 more
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p-Synephrine and its various pharmacological effects [PDF]
There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological activity from plants gives hope for its use in treatment.
Ziemichod Wojciech +4 more
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Self-reporting molecularly imprinted polymer with the covalently immobilized ferrocene redox probe for selective electrochemical sensing of p-synephrine [PDF]
Molecularly imprinted polymers (MIPs) belong to the illustrious examples of bio-mimicking recognizing materials.1 They have found numerous applications in the fabrication of selective chemosensors.2 Their analytical parameters, such as sensitivity, selectivity, and detectability, are almost as high as those of biosensors.
Patrycja Lach +9 more
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Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using <sup>1</sup>H NMR spectroscopy. [PDF]
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Davies EC +3 more
europepmc +2 more sources
Acute consumption of p-synephrine does not enhance performance in sprint athletes
P-Synephrine is a protoalkaloid widely used as an ergogenic aid in sports. This substance has been included in the World Anti-Doping Agency monitoring program, although scientific information about its effects on performance and athletes’ well-being is scarce.
Gutiérrez, Jorge +7 more
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Self-Reporting Molecularly Imprinted Polymer for Label-Free Selective Electrochemical Sensing of p-synephrine [PDF]
Molecularly imprinted polymers (MIPs) are excellent example of bio-mimicking recognition [...]
Patrycja Lach +5 more
doaj +3 more sources
PHYSICAL STABILITY TESTING OF P-SYNEPHRINE PREPARED AS TRANSFERSOME GEL
Objectives: While p-synephrine exhibits lipolytic activity, it also has a low oral bioavailability as well as hydrophilic characteristic, so it is difficult forit to penetrate the epidermis if it is made into transdermal preparation. The purpose of this research was to increase the penetration of p-synephrineby preparing it as transfersome gel ...
Amelia Luthfiah +2 more
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