Results 241 to 250 of about 34,114,673 (279)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The false evidence rate: An approach to frequentist error rate control conditioning on the observed P value. [PDF]

Proc Natl Acad Sci U S A
Crouch DJM.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The null hypothesis significance test and the dichotomization of the p-value: Errare Humanum Est. [PDF]

Rev Peru Med Exp Salud Publica
Mezones-Holguín E, Al-Kassab-Córdova A, Soto-Becerra P, Hernández-Díaz S, Kaufman JS.   +4 more
europepmc   +1 more source

[The p-value of a test is not the probability that the null hypothesis is true or false]. [PDF]

Rev Neurol
Carazo-Díaz C, Prieto-Valiente L.
europepmc   +1 more source

[The p-value of the test is not a 'mathematical index', it is simply a relative frequency]. [PDF]

Rev Neurol
Carazo-Díaz C, Prieto-Valiente L.
europepmc   +1 more source

DisCo P-ad: Distance-Correlation-Based p-Value Adjustment Enhances Multiple Testing Corrections for Metabolomics. [PDF]

Metabolites
Nandy D, Ghosh D, Kechris K.
europepmc   +1 more source