Results 81 to 90 of about 34,114,673 (279)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Definitions and meanings of value

, 2017
This chapter gives an introduction to The Value of Events and sets the stage for subsequent contributions by providing an overview of the most fundamental concepts.
Tommy D. Andersson, Donald Getz, Andersson, Tommy D.,, Erik Lundberg, John Armbrecht, Getz, Donald,, Armbrecht, John,, Lundberg, Erik,   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficient Computation of the Shapley Value for Centrality in Networks

, 2010
The Shapley Value is arguably the most important normative solution concept in coalitional games. One of its applications is in the domain of networks, where the Shapley Value is used to measure the relative importance of individual nodes.
Michalak, Tomasz P, Michalak, Tomasz P., Ravindran, Balaraman, Aadithya, Karthik V., Nicholas R. Jennings, Jennings, Nicholas R., Jennings, Nicholas R, Aadithya, Karthik V, Karthik V. Aadithya, Balaraman Ravindran, Tomasz P. Michalak   +10 more
core   +2 more sources

Testing with p*-values: Between p-values, mid p-values, and e-values

Bernoulli
38 pages, 5 ...
openaire   +3 more sources

Shareholder value creators in the S&P 500: Year 2003 [PDF]

During 2003, 87% of the companies in the S&P 500 created value, compared to just 17% in 2002. The market value of the 500 companies in 2003 was $10.1 trillion, compared to $7.9 trillion in 2002.
Fernandez, Pablo, Reinoso, Laura
core  

Value and time

, 2015
This chapter discusses time and value. The two main questions are: What is the time of value? and What is the value of time? The first main question splits into two: Does what has value always have a temporal location? and Does value itself have temporal
Bykvist, Krister,
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source