Results 91 to 100 of about 43,193,860 (312)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Accuracy evaluation of API P-Y model for Offshore Piles in Clays

Results in Engineering
Piles are widely used as foundation structures supporting offshore wind turbines, with the p-y curve method commonly recommended for analysis of pile-soil interactions by current mainstream design specifications.
Peiyuan Lin, Xun Yuan, Tong Liu, Haoyi Li, Xiangwei Yu   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Experimental and Numerical Research on p-y Curve of Offshore Photovoltaic Pile Foundations on Sandy Soil Foundation

Journal of Marine Science and Engineering
While methods like cyclic triaxial testing and p-y model updating theory exist in geotechnical and offshore wind engineering, they have not been systematically applied to solve the specific deformation problems of offshore PV piles.
Sai Fu, Hongxin Chen, Guo-er Lv, Xianlin Jia, Xibin Li   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Nonstationarity in the Specification of the Environmental Kuznets Curve [PDF]

Numerous studies have addressed the question of the econometric specification of the Environmental Kuznets Curve (EKC). This paper adds preliminary results on nonstationarity and its effect on functional form using a panel data set for the U.S.
Zapata, Hector O., Paudel, Krishna P.
core  

The Beveridge Curve in Europe: New evidence using national and regional data [PDF]

, 2009
In this paper, national and regional data on job vacancies and unemployment are combined to estimate the Beveridge curves of five European countries and 60 regions, focusing on the period 1975-2004.
Bouvet, Florence.
core  

Lateral load capacity of flexible piles in the SDMC model with cylindrical cavity expansion theory

Scientific Reports
This paper presents a method for calculating the lateral load capacity of flexible piles based on the state-dependent Mohr-Coulomb (SDMC) model combined with cylindrical cavity expansion theory. The soil surrounding the pile is idealized as a cylindrical
Feng Gao, Chengcong Hu, Biao Huang, Li Pang   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source