Results 81 to 90 of about 889,323 (267)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Applicability Analysis of HS Model in Large Diameter Monopile Foundation Engineering

Renmin Zhujiang, 2020
The ultimate bearing capacity of the monopile foundation of an offshore wind turbine iscontrolled by the foundation deformation. It is very important to select the appropriate soilconstitutive model in the analysis and design of monopile foundation ...
PAN Bing, CHU Weijiang
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Horizontal Bearing Characteristics of Pile Foundation Considering the Influence of Temperature and Freeze-thaw Cycles

工程科学与技术, 2021
The influence of temperature and freezing-thawing cycles on the horizontal bearing mechanism of frozen soil foundation pile has not been clarified, and the calculation method of horizontal bearing force and deformation of foundation pile still needs to ...
Pingbao YIN, Kaibo YANG, Zhaohui YANG, Wei HE, Wei YU   +4 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Accuracy evaluation of API P-Y model for Offshore Piles in Clays

Results in Engineering
Piles are widely used as foundation structures supporting offshore wind turbines, with the p-y curve method commonly recommended for analysis of pile-soil interactions by current mainstream design specifications.
Peiyuan Lin, Xun Yuan, Tong Liu, Haoyi Li, Xiangwei Yu   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Experimental and Numerical Research on p-y Curve of Offshore Photovoltaic Pile Foundations on Sandy Soil Foundation

Journal of Marine Science and Engineering
While methods like cyclic triaxial testing and p-y model updating theory exist in geotechnical and offshore wind engineering, they have not been systematically applied to solve the specific deformation problems of offshore PV piles.
Sai Fu, Hongxin Chen, Guo-er Lv, Xianlin Jia, Xibin Li   +4 more
doaj   +1 more source