Results 121 to 130 of about 889,323 (267)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Numerical Centrifugal Test Study on Large-diameter Steel Pipe Pile under Horizontal Load
工程科学与技术, 2016 :Large-diameter steel pipe pile is a kind of single pile which is widely used in offshore wide farm. Based on the centrifugal model test results of large-diameter steel pipe pile under horizontal load, we conducted the centrifugal numerical test by 3D ...
jiang jiwei
doaj
MODELING AND EVALUATION OF P-Y CURVES OF SINGLE PILE IN SAND
Doboku Gakkai Ronbunshu, 2000 Masayuki KODA +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Revista Integración, 1997 Resumen Se ajustaron 5 modelos de crecimiento a un grupo de 12 variedades y 26 progenies (postura y ciones) de caña de azúcar, las que fueron caracterizadas por sus mecanismos epidemiológicosde resistencia a la roya (P.
Lydia Lera +2 more
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Le Matematiche, 2002 Let Y be an elliptic curve, p a prime number and WH_{p,n}(Y) the Hurwitz space that parametrizes equivalence classes of p-sheeted branched coverings of Y , with n branch points, n − 1 of which are points of simple ramification and one of total ...
Francesca Vetro
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source