Results 121 to 130 of about 43,193,860 (312)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Video (sound only, no image) of a man remembering taking part in a play at Curve
, 2014 A video (duration 34 seconds) with the image blanked out , the audio is a man talking about his positive memories of taking part in the play "East" by Stephen Berkoff at Curve, directed by Paul Kerryson, and how the experience influenced his future.When ...
Anonymous;
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The J-Curve Phenomenon: Myth or Reality? [PDF]
This study examines the J-curve phenomenon for the U.S. agricultural trade and compares the effect on agricultural trade relative to the U.S. non-agricultural trade. For this purpose, the autoregressive distributed lag (ARDL) model is adopted to estimate
Koo, Won W., Baek, Jungho, Mulik, Kranti
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Levelness Analysis of Subsea Wellhead Subjected to Lateral Load
Shiyou jixie, 2019 To ensure the levelness of the subsea wellhead and make sure that it does not produce large inclination in deep water to avoid damage to the wellhead equipment, the surface conductor and cementing sheath that fix the subsea wellhead system are treated as
Zhong Gongxiang +2 more
doaj
南方能源建设[Objective] As a key pathway toward developing clean and renewable energy, offshore wind power plays a vital role in mitigating global energy shortages and advancing the "dual-carbon" goals.
Hexing SONG +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Bilateral J-Curve Between Thailand and Her Trading Partners [PDF]
Previous studies that tested the J-Curve phenomenon, employed aggregate trade data. More recent studies however, have used bilateral data in testing the phenomenon. They have all concentrated investigating the J-Curve between the U.S.
Tatchawan Kantipong +1 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source