Results 141 to 150 of about 43,193,860 (312)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Learning Curve and Durable-Goods Production [PDF]
We investigate the effect of a learning curve on the production of durable goods by examining a durable-goods monopolist in a two-period model. If the monopolist faces a learning curve, the model shows that the equilibrium quantity of the first- (second-)
Atsuo Utaka
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Yield Curve Dynamics: Regional Common Factor Model [PDF]
In this paper, we focus on thorough yield curve modelling. We build on extended classical Nelson-Siegel model, which we further develop to accommodate unobserved regional common factors.
Boril Šopov, Jakub Seidler
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
MODELING AND EVALUATION OF P-Y CURVES OF SINGLE PILE IN SAND
Doboku Gakkai Ronbunshu, 2000 Masayuki KODA +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Curve and G-Spot at Christmas, 2009
, 2009 A colour photograph of the Queen's Building, 37-43 Rutland Street, the G-Spot club and the new Curve theatre opposite. Built in 1897 and likely named for Queen Victoria’s diamond jubilee, the Queen's Building was Grade II listed in ...
Hyde, Colin;
core
p-y Curves for Piles in Uniform Sand and Normally Consolidated Clay
Abstract The design of laterally loaded piles has commonly been done using the p-y method. The results of a p-y analysis are highly dependent on the p-y curves used in the analysis. Since the p-y curves routinely used in p-y analyses have been traditionally derived empirically from data obtained from a limited number of lateral pile load tests ...
YAO WANG, Rodrigo Salgado, Monica Prezzi
openaire +1 more source