Results 41 to 50 of about 717,769 (266)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Bounding surface plastic p-y model for a single laterally loaded pile in sand

Yantu gongcheng xuebao, 2023
In ocean engineering practice, laterally loaded piles are usually analyzed using the nonlinear Winkler foundation beam method, in which the soil-structure interaction is modelled by means of the p-y curve, but now the API/DNV rules are only valid for few
WANG Mingyuan 1, SUN Jizhu 2, WANG Yong 3, YANG Yang 4
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Numerical Analysis of Laterally Loaded Piles Affected by Bedrock Depth

Advances in Civil Engineering, 2018
This study investigates the lateral behavior of pile foundations socketed into bedrocks using 3D finite difference analysis. The lateral load-displacement curve, pile deflection, and bending moment distribution were obtained for different bedrock depths ...
Younggyun Choi, Janghwan Kim, Heejung Youn   +2 more
doaj   +1 more source

Parafuso pedicular: método para correção da deformidade na escoliose idiopática do adolescente Tornillo pedicular: método para corregir la deformidad en la escoliosis idiopática del adolescente Pedicular screw: method to correct the deformity in adolescent idiopatic scoliosis

Coluna/Columna, 2010
OBJETIVO: avaliar retrospectivamente o poder de correção da deformidade escoliótica em pacientes tratados cirurgicamente com instrumental de terceira geração sendo utilizados exclusivamente parafusos pediculares tanto nas curvas torácicas quanto nas ...
Raphael de Rezende Pratali, Marcelo Italo Risso Neto, Ivan Guidolin Veiga, Wagner Pasqualini, Paulo Tadeu Maia Cavali, Marcus Alexandre Mello Santos, Alexander Junqueira Rossato, Maurício Antonelli Lehoczki, Élcio Landim   +8 more
doaj   +1 more source

Asymptotic behavior of solution curves of nonlocal one-dimensional elliptic equations

Boundary Value Problems, 2022
We study the one-dimensional nonlocal elliptic equation − A ( ∥ u ′ ∥ p p ) u ″ ( x ) = λ B ( ∥ u ′ ∥ q q ) u ( x ) r , x ∈ I : = ( 0 , 1 ) , u ( x ) > 0 , x ∈ I , u ( 0 ) = u ( 1 ) = 0 , $$\begin{aligned}& -A\bigl( \bigl\Vert u' \bigr\Vert _{p}^{p ...
Tetsutaro Shibata
doaj   +1 more source

Design of Laterally Loaded Piles in Cohesive Soils Using p-y Curves

Soils and Foundations, 1998
ABSTRACT The paper presents the results from a series of tests in Shanghai, PRC on laterally loaded single piles in a medium stiff clay. The diameter of the piles varied from 0.09 m to 0.60 m. The piles were instrumented with strain gauges to determine the moment distribution along the piles and the lateral deflections.
WU, DONGQING, BROMS, BENGT B., CHOA, VICTOR   +2 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

New hybrid foundation solutions for offshore wind turbines [PDF]

Archives of Civil Engineering
This paper reviews latest developments of substructures for offshore wind turbines focusing on investigations and applications of hybrid foundations. Model tests and numerical analyses were used to simulate the loading of hybrid piles in sand.
Krzysztof Trojnar
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source