Results 131 to 140 of about 24,188,006 (246)

Origin and dissemination across the Colombian Andes mountain range of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum.

, 2010
The therapeutic efficacy of sulfadoxine-pyrimethamine (SP) in treating uncomplicated Plasmodium falciparum malaria is unevenly distributed in Colombia. The Andes mountain range separates regions in the west where malaria is endemic from those in the east
Osorio, Lyda, GUERRA, ANGELA, Echeverry, Diego F, Roper, Cally, Guerra, Angela P, ECHEVERRY, DIEGO, PEARCE, RICHARD, Corredor, Vladimir, CORREDOR ESPINEL, VLADIMIR, Murillo, Claribel, Benavides, Julie, Pearce, Richard J, Benavides Melo, Julie, Fernández-Cruz K.A., Poblano A., Castro-López C., Marin Agudelo, Hernan Andres, Jiménez-Correa U.   +17 more
core   +1 more source

Synthesis, antimalarial activity, and in silico study of pyridine-based N-phenylpyrazoline

Results in Chemistry
Resistance to chloroquine has driven the search for antimalarial agents targeting non–heme-based metabolic pathways. In this study, a series of pyridine-containing N-phenylpyrazoline derivatives (NP1–NP7) were rationally designed as potential inhibitors ...
Halimah Syaadiyah, Fia Fathiana Wulan, Tutik Dwi Wahyuningsih, Endang Astuti   +3 more
doaj   +1 more source

N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier, Marco Antônio G. B. Gomes, Mariam Salim, Maxime Guichonnet, Michel Nguyen, Laure Vendier, Flore Nardella, Jean‐Michel Augereau, Dennis Gomez, Anne Robert, Françoise Benoit‐Vical   +10 more
wiley   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source

Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45.

, 2007
Targeted disruption of particular members of the Plasmodium 6-cys protein gene family, including Ps47, Ps48/45 and Ps230, is known to dramatically affect parasite fertility.
Conway, David J, Anthony, Thomas G, Polley, Spencer D, Vogler, Alfried P   +3 more
core   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

First field evaluation of novel LDH- and HRP2-based rapid tests for Plasmodium vivax and Plasmodium falciparum malaria diagnosis.

PLoS Neglected Tropical Diseases
BackgroundRapid diagnostic tests (RDTs) are crucial for malaria diagnosis. Where Plasmodium falciparum and Plasmodium vivax are co-endemic, and where P. falciparum hrp2/3 deletions are frequent, RDTs need to detect either species, and P. falciparum using
Colins O Oduma, Birhanu Lulu, Yalemwork Ewnetu, Laurel A Lown, Tolulope Adeyemi Kayode, Dawit Hawaria, Cristian Koepfli   +6 more
doaj   +1 more source

Retinal haemorrhage in P falciparum malaria

The Lancet, 2002
Newton, P, Michelson, G, Ruangveerayuth, R, White, N   +3 more
openaire   +3 more sources

Prevalence of asymptomatic non-falciparum and falciparum malaria in the 2014-15 Rwanda Demographic Health Survey.

PLoS ONE
BackgroundRecent molecular surveillance suggests an unexpectedly high prevalence of non-falciparum malaria in Africa. Malaria control is also challenged by undetected asymptomatic P. falciparum malaria resulting in an undetectable reservoir for potential
Claudia Gaither, Camille Morgan, Rebecca Kirby, Corine Karema, Pierre Gashema, Jenna Zuromski, Samuel J White, Hillary M Topazian, David Giesbrecht, Kyaw Thwai, Neeva Wernsman Young, Varun Goel, Koby Boyter, Tharcisse Munyaneza, Claude Mambo Muvunyi, Jean De Dieu Butera, Jeffrey A Bailey, Jean-Baptiste Mazarati, Jonathan J Juliano   +18 more
doaj   +1 more source