Results 121 to 130 of about 24,188,006 (246)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Emprego da associação tetraciclina e quinino no tratamento da malária causada pelo Plasmodium falciparum

Revista da Sociedade Brasileira de Medicina Tropical, 1986
Cento e dez pacientes com malária falciparum não complicada, provenientes da Amazônia brasileira, foram tratados com cloridrato de tetraciclina, na dose de 250 mg a cada 6 horas por 7 dias, associado ao sulfato de quinino na dose de 1,5 a 2,0 gramas/dia ...
L.C.B. Barata, M. Boulos, A.P. Dutra
doaj  

The assembly of tetrameric human L‐lactate dehydrogenase is regulated by ionic strength, β‐NADH binding, cyclic peptides, and long‐chain dicarboxylates

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Lactate dehydrogenases catalyze the reduction of pyruvate to lactate, the generation of which is of importance for the energetic metabolism of malignant cells. In particular, human cancer cells overexpress lactate dehydrogenase A (hLDH‐A), whose catalytic activity depends on its assembly into the corresponding homotetramer (denoted as hLDH‐5),
Alessandra Stefan, Luca Gentilucci, Alberto Giuseppe Barbiroli, Valentina Rossi, Hang Liao, Giuseppina Di Stefano, Tingting He, Alejandro Hochkoeppler   +7 more
wiley   +1 more source

P. falciparum malaria recrudescence in a cancer patient.

Le infezioni in medicina, 2009
Persons living for long periods of time in malaria hyper-endemic areas may suffer from hyper-reactive malarial splenomegaly (HMS), a frequent cause of splenomegaly in such areas. Splenomegaly and sub-microscopic P. falciparum parasitaemia are hallmarks of HMS.
FOCA', Emanuele, ZULLI, Roberto, Buelli F, De Vecchi M, Regazzoli A, CASTELLI, Francesco   +5 more
openaire   +2 more sources

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

, 2006
In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT).
van Overmeir, C, Karema, Corine, Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., van Doren, W., van Doren, W, Karema, C., Fanello, Caterina I, Fanello, Caterina I., D'Alessandro, Umberto, Van Overmeir, C., Fanello, CI, d' Alessandro, Umberto, van Geertruyden, Jean-Pierre, Ngamije, Daniel, van Overmeir, Chantal, van Doren, Walli, D'Alessandro, U, Karema, C, van Geertruyden, JP, Van Geertruyden, J. P.   +22 more
core   +1 more source

Assessing the Use of Oxford Nanopore Technologies Sequencing for Detection of Stable Wolbachia Bacterial Strain in Symbiosis in Wild Anopheles Mosquitoes From the WHO African Region

Environmental Microbiology, Volume 28, Issue 10, October 2026.
This study assesses Oxford Nanopore Technology sequencing to detect Wolbachia in Anopheles mosquitoes. To do this, samples were analysed using the ONT field sequencing kit and sequenced using a minION flow cell and the ONT 16S barcoding kit and Rapid barcoding kit sequenced using Flongle flow cells.
Laura Chatterley, Nicola Hull, Isabel Hughes, Seynabou Sougoufara, Owain Meek, Murat Ceyran, Vishaal Dhokiya, Janvier Bandibabone, Cyprian Adala, Elin Cunningham, Shehu Shagari Awandu, Helene Kaminski‐Nenkam, Antonio Nkondjio, Grant L. Hughes, Eva Heinz, Thomas Walker   +15 more
wiley   +1 more source

Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the MiPPAD Birth Cohort Study of Benin

Tropical Medicine &International Health, Volume 31, Issue 10, Page 1395-1407, October 2026.
ABSTRACT In malaria‐endemic regions, repeated episodes of uncomplicated malaria during infancy are common; however, their associations with neurodevelopment remain unclear. We examined relationships between malaria frequency in infancy and neurodevelopmental outcomes in early and middle childhood, using data from the APEC birth cohort nested within the
Juthathip Khongpetch, Michael J. Boivin, Michel Cot, Jacqueline Milet, Roméo Zoumenou, Christophe Fermanian, Achille Massougbodji, Florence Bodeau‐Livinec   +7 more
wiley   +1 more source

Validation of Health Belief Model and Theory of Planned Behaviour Constructs for Predicting Malaria Vaccine Acceptance in Ghana: A Partial Least Squares Structural Equation Modelling Approach

Tropical Medicine &International Health, Volume 31, Issue 10, Page 1443-1452, October 2026.
ABSTRACT Aim This study examines the predictive power of constructs from the health belief model (HBM) and theory of planned behaviour (TPB) in explaining malaria vaccine acceptance in Ghana in the post‐COVID‐19 era, while also assessing the reliability of these constructs within this context.
Michael Sarfo, Michael Snowden, Jamie P. Halsall   +2 more
wiley   +1 more source

Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic‐vasodilatory shock

Experimental Physiology, Volume 111, Issue 10, Page 4421-4434, 1 October 2026.
Abstract Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the venous circulation with centhaquine improves circulatory ...
Athanasios Chalkias, Aman Khanna, Krish Vaidya, Dharmesh Shah, Anil Gulati   +4 more
wiley   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source