Results 101 to 110 of about 145,240 (241)

Transfusion‐transmitted malaria in India: A national survey of epidemiology and testing practices

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Malaria still poses a public health burden in India despite ongoing elimination efforts. Blood donor screening for malaria is mandated in India, yet data on transfusion‐transmitted malaria (TTM) are lacking. We sought to evaluate testing practices for malaria, associated rates of positivity in donors and reported ...
Jeremy W. Jacobs, Nabajyoti Choudhury, Satyam Arora, Aikaj Jindal, Nidhi Bhatnagar, Abhishekh Basavarajegowda, Shamee Shastry, Tulika Chandra, David Daniel, Steven J. Drews, Evan M. Bloch   +10 more
wiley   +1 more source

Efek Pemberian ?-Mangostin dari Garcinia tetranda Pierre Terhadap Morfologi P.falciparum

Journal of Tropical Pharmacy and Chemistry, 2011
Morphological changes assay to P. falciparum from the effects of α-mangostin from G. tetranda using TEM methods has been done. This test aims to determine the effect of mangostin on P.
Hadi Kuncoro
doaj   +1 more source

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Early‐stage drug discovery relies on the availability of stable protein for reliable biophysical characterization of ligand binding. However, many Plasmodium falciparum proteins are challenging to produce in heterologous systems, which limits their experimental utility.
Marius Amann, Tim Sträßer, Oliver Einsle, Stefan Günther   +3 more
wiley   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

The contribution of non-malarial febrile illness co-infections to Plasmodium falciparum case counts in health facilities in sub-Saharan Africa

Malaria Journal, 2019
Background The disease burden of Plasmodium falciparum malaria illness is generally estimated using one of two distinct approaches: either by transforming P. falciparum infection prevalence estimates into incidence estimates using conversion formulae; or
Ursula Dalrymple, Ewan Cameron, Rohan Arambepola, Katherine E. Battle, Elisabeth G. Chestnutt, Suzanne H. Keddie, Katherine A. Twohig, Daniel A. Pfeffer, Harry S. Gibson, Daniel J. Weiss, Samir Bhatt, Peter W. Gething   +11 more
doaj   +1 more source

Exploring Passive Permeability Profiles of Cyclic Heptapeptide Chemical Space Uncovers Bioactivity of Mortiamide Scaffold Driven by Colloidal Aggregation

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
A comprehensive stereochemical and physicochemical survey of cyclic heptapeptide chemical space reveals that the mortiamide natural product scaffold possesses intrinsically low aqueous solubility and forms amyloid‐like fibril aggregates. Multiple orthogonal assays demonstrate that the observed cytotoxicity arises from colloidal aggregation rather than ...
Jaru Taechalertpaisarn, Alexander Engstrom, Maria Sajimon, Beverley M. Rabbitts, Vitor H. Balasco Serrão, Satoshi Ono, Jevgenij A. Raskatov, Timothy C. Johnstone, R. Scott Lokey   +8 more
wiley   +1 more source

REAPR: a universal tool for genome assembly evaluation. [PDF]

, 2013
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked.
Berriman, Matthew, Hunt, Martin, Kikuchi, Taisei, Newbold, Chris, Otto, Thomas D, Sanders, Mandy   +5 more
core   +2 more sources

A New Conditional Transcription Factor for Use in Toxoplasma Gondii

Biotechnology Journal, Volume 21, Issue 5, May 2026.
Graphical Abstract and Lay Summary A new conditional transcription factor (CTF) for Toxoplasma gondii reversibly regulates a reporter gene, achieving an outstanding signal‐to‐noise ratio. Gene expression is robust in the absence and nearly abolished in the presence of rapamycin, and the tool's modular design will facilitate application to varied genes ...
Mohammad Farouq Sharifpour, Shadi Khadiv, Alessandro D. Uboldi, Amalie A. Jayawickrama, Sarah Manning, Jonathan Whittall, Cynthia D. K. Bottema, John T. Ellis, Daniel K. Howe, Danny W. Wilson, Farhid Hemmatzadeh, Christopher J. Tonkin, Milton M. McAllister   +12 more
wiley   +1 more source

Serum enzymes activities in Plasmodium falciparum infection in Southern Pakistan [PDF]

Archives of Pharmacy Practice, 2011
Objective: Serum levels of lactate dehydrogenase (LDH),aspartate aminotranferase (AST), alanine aminotransferase(ALT), and alkaline phosphatase (ALP) were assessed todetermine the liver functions of patients infected withPlasmodium falciparum. The enzyme
Koay Yen Chin, Memon Sikander Ali, Faheem Amir, Khurram Ghani   +3 more
doaj