Results 81 to 90 of about 66,832 (203)
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Amanda Mohr +4 more
wiley +1 more source
Estudos "in vitro" dos níveis de resistência do Plasmodium falciparum a drogas, de 1983 a 1986
Foram realizados 171 testes de sensibilidade (microtécnica) com cepas de Plasmodium falciparum da Região Amazônica brasileira para cloroquina, mefloquina, amodiaquina e quinino.
M. A. V. Santos +3 more
doaj +1 more source
Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu +4 more
wiley +1 more source
ABSTRACT Background and Aims Malaria and anemia remain major public health challenges contributing substantially to morbidity and mortality among children under 5 years in sub‐Saharan Africa (SSA). Although conventional regression analyses have reported a significant association between malaria infection and anemia, these approaches often inadequately ...
Edson Mwebesa +9 more
wiley +1 more source
ABSTRACT Background Malaria is a critical public health concern in Nigeria with the country bearing an uneven burden of the disease. In Nigeria, malaria is one of the main causes of child mortality and despite all efforts to reduce malaria mortality rates, the disease remains a major concern, notably among children under‐fives.
Justice Moses K. Aheto +23 more
wiley +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Cento e dez pacientes com malária falciparum não complicada, provenientes da Amazônia brasileira, foram tratados com cloridrato de tetraciclina, na dose de 250 mg a cada 6 horas por 7 dias, associado ao sulfato de quinino na dose de 1,5 a 2,0 gramas/dia ...
L.C.B. Barata, M. Boulos, A.P. Dutra
doaj
Improving Malaria Parasite Gene Flow Inference Under Sparse Spatial Sampling
ABSTRACT Estimating malaria parasite migration is crucial for informing elimination strategies, particularly by identifying regions with higher parasite migration that may serve as transmission sources and intervention targets. Methods that infer spatial variations in gene flow from georeferenced genetic data, including Estimated Effective Migration ...
Yao Li +4 more
wiley +1 more source
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter +19 more
wiley +1 more source
ABSTRACT Malaria remains a significant global health burden, particularly among pediatric populations in endemic regions. Recent advances in preventive interventions highlight the complementary roles of vaccines and long‐acting monoclonal antibodies (mAbs) in reducing infection risk.
Sabiha R. Mim +3 more
wiley +1 more source

