Results 61 to 70 of about 145,240 (241)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

An Unfolding Story: AlphaFold's View on Protein Flexibility

Helvetica Chimica Acta, EarlyView.
AlphaFold confidence measures allow for detailed proteome‐wide characterization of protein flexibility. All flexibility measures increased substantially in the evolutionary transition from prokaryota to eukaryota. ABSTRACT The AlphaFold confidence measures are related to conformation distribution of the protein.
Gunnar Jeschke
wiley   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

PNAS plus: plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state [PDF]

, 2012
The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this ...
Baertl, Bozdech, Brennand, C. Doerig, C. Fennell, Callebaut, Codd, D. E. Goldberg, Daily, Dever, Divo, Dyer, E. S. Istvan, Fennell, Fidock, Francis, Functional Genomics Workshop Group, Harris, Hinnebusch, Hinnebusch, Kafsack, Kilberg, Kim, Kourtis, L. Altenhofen, Lambros, Llinas, Lu, Lu, M. Llinas, Olszewski, Payne, Pfaller, Roth, Russo, S. A. Cobbold, S. E. Babbitt, Sharma, Sherman, Sims, Soeters, Towbin, Trager, van Werven, Wek, Zaborske, Zolg   +46 more
core   +1 more source

Solar Geoengineering Effects on Malaria Transmission Risk in South Asia Under G6sulfur Scenario

International Journal of Climatology, EarlyView.
Comparison of EIR (unit: No of infected bites per person per day) for each considered country in South Asia, under the considered scenarios, averaged over the period 2020–2090. A regression equation is shown for each country (for Bhutan EIRG = 0.1690 × 10−10 EIRS + 0.5968 × 10−12) to illustrate the projected trend.
Athar Hussain, Muhammad Ali Khan, Muhammad Shoaib   +2 more
wiley   +1 more source

Resistência à mefloquina do tipo RIII em crianças com malária falciparum em Manaus, AM, Brasil RIII mefloquine resistance in children with falciparum malaria in Manaus, AM, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2000
Relata-se a ocorrência de resistência à mefloquina administrada na dose de 20mg/kg em 51 crianças com malária falciparum atendidas em centro de referência em Manaus, Brasil, no período de outubro a novembro de 1997.
Elza Noronha, Maria das Graças Alecrim, Gustavo Adolfo Sierra Romero, Vanize Macêdo   +3 more
doaj   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

High prevalence of malaria infection in Amazonas state, Venezuela Incidencia de malaria en una región endémica del estado Amazonas, Venezuela

Revista do Instituto de Medicina Tropical de São Paulo, 2007
This study was carried out to determine the incidence of malaria in an endemic region of Amazonas State, Venezuela. For this, 200 random samples were collected from symptomatic and asymptomatic individuals from San Fernando de Atabapo and Santa Barbara ...
Hectorina Rodulfo, Marcos de Donato, Isaurea Quijada, Ada Peña   +3 more
doaj   +1 more source

Community-based Approach to Intermittent Preventive Treatment for Malaria in Pregnancy in Kisumu, Kenya [PDF]

, 2014
Malaria in pregnancy (MiP) is a significant contributor to maternal and newborn morbidity and mortality. In malaria-endemic countries, especially those in tropical areas of Africa where there is intense transmission of Plasmodium falciparum (P ...

core  

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, EarlyView.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source