Results 51 to 60 of about 66,832 (203)

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Aktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2017
Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity.
Wiwied Ekasari, Nindya Tresiana, Suciati Iryani, Tutik Sri Wahyuni, Heny Arwaty   +4 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Unfolding the Genome: The Case Study of P. falciparum [PDF]

The International Journal of Biostatistics, 2018
Abstract The development of new ways to probe samples for the three-dimensional (3D) structure of DNA paves the way for in depth and systematic analyses of the genome architecture. 3C-like methods coupled with high-throughput sequencing can now assess physical interactions between pairs of loci in a genome-wide fashion, thus enabling ...
openaire   +3 more sources

Effects of Video‐Based Health Education on Birth Outcomes and Anaemia Status of Mothers in Dirashe District South Ethiopia: A Cluster Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
ABSTRACT Undernutrition and infections during pregnancy result in low birth weight (LBW) and maternal anaemia. Social behaviour change communication (SBCC) can promote recommended health practices, potentially improving maternal and neonatal outcomes.
Wanzahun Godana Boynito, Kidus Temesgen Worsa, Befikadu Tariku Gutema, Yordanos Gizachew Yeshitila, Godana Yaya Tessema, Tsegaye Yohanis, Stefaan De Henauw, Piet Cools, Bruno Levecke, Souheila Abbeddou   +9 more
wiley   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Indoor residual spraying of distinct insecticide formulations in a household‐scale micro‐mosaic format: Feasibility and effectiveness for malaria vector control in rural Zambia

Medical and Veterinary Entomology, EarlyView.
Densities of all Anopheles species were approximately comparable across all IRS regimes. No differences observed between treatment regimes regarding species composition of the Anopheles funestus group or An. gambiae complex. This operational pilot demonstrates the practical feasibility of IRS micro‐mosaics, despite the inherent increase in deployment ...
Dingani Chinula, Kenzo Mumba, Reuben Zulu, Ketty Ndhlovu, Deogratius R. Kavishe, Neil Philip Hobbs, Samson Kiware, Thomas Reed, Busiku Hamainza, Gerry F. Killeen   +9 more
wiley   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source

Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the MiPPAD Birth Cohort Study of Benin

Tropical Medicine &International Health, EarlyView.
ABSTRACT In malaria‐endemic regions, repeated episodes of uncomplicated malaria during infancy are common; however, their associations with neurodevelopment remain unclear. We examined relationships between malaria frequency in infancy and neurodevelopmental outcomes in early and middle childhood, using data from the APEC birth cohort nested within the
Juthathip Khongpetch, Michael J. Boivin, Michel Cot, Jacqueline Milet, Roméo Zoumenou, Christophe Fermanian, Achille Massougbodji, Florence Bodeau‐Livinec   +7 more
wiley   +1 more source