Results 31 to 40 of about 145,240 (241)

Mechanisms for Host Immune Evasion Mediated by Plasmodium falciparum-Infected Erythrocyte Surface Antigens

Frontiers in Immunology, 2022
Plasmodium falciparum infection causes the most severe form of malaria. It has been hypothesized that P. falciparum directly suppresses host immune responses because sufficient acquired immunity is often not induced even by repeated P.
Akihito Sakoguchi, Hisashi Arase, Hisashi Arase, Hisashi Arase   +3 more
doaj   +1 more source

Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment [PDF]

, 2014
During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, a consistently high malaria prevalence was observed in young children despite regular treatment.
AARON ATUHAIRE, COLIN J. SUTHERLAND, Dinko, Felger, Fogg, GERALD MWESIGWA, J. RUSSELL STOTHARD, JOSÉ C. SOUSA-FIGUEIREDO, JUMA NABONGE, Katz, MARTHA BETSON, MOSES ADRIKO, MOSES ARINAITWE, NARCIS B. KABATEREINE   +13 more
core   +5 more sources

The genetic landscape of origins of replication in P. falciparum. [PDF]

Nucleic Acids Res, 2023
Abstract Various origin mapping approaches have enabled genome-wide identification of origins of replication (ORI) in model organisms, but only a few studies have focused on divergent organisms. By employing three complementary approaches we provide a high-resolution map of ORIs in Plasmodium falciparum, the deadliest human malaria ...
Castellano CM, Lacroix L, Mathis E, Prorok P, Hennion M, Lopez-Rubio JJ, Méchali M, Gomes AR.   +7 more
europepmc   +4 more sources

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

Mefloquine in the Prophylaxis ofP. FalciparumMalaria [PDF]

Journal of Travel Medicine, 1995
Background: The objectives of this study were (1) to compare the efficacy of Lariam (mefloquine) with that of Fansimef (mefloquine, sulfadoxine, and pyrimethamine), Fansidar (sulfadoxine and pyrimethamine), chloroquine, and placebo in suppressing asexual parasitemia in semi-immune persons living in an area endemic for Plasmodium falciparum malaria; and
, Sossouhounto, , Soro, , Coulibaly, , Mittelholzer, , Stuerchler, , Haller   +5 more
openaire   +2 more sources

Malaria in Mazandaran, Northern Iran: Passive Case Finding During 1997-2012 [PDF]

Iranian Journal of Parasitology, 2012
Background: Malaria is one of the most important parasitic diseases in tropical and temperate regions. The aim of this study was to determine the trend of malaria in Mazandaran Province, northern Iran during 1997-2012.
S Ghaffari, SA Mahdavi, Z Moulana, S Mouodi, H Karimi-Nia, M Bayani, N Kalantari   +6 more
doaj   +1 more source

Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomized safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine, and primaquine in healthy Thai adult volunteers

Human Vaccines & Immunotherapeutics, 2020
Introduction: RTS,S/AS01 is currently the most advanced malaria vaccine but provides incomplete, short-term protection. It was developed for use within the expanded program on immunizations (EPI) for African children. Another use could be adding mass RTS,
Lorenz von Seidlein, Borimas Hanboonkunupakarn, Podjanee Jittamala, Pongphaya Pongsuwan, Kesinee Chotivanich, Joel Tarning, Richard M. Hoglund, Markus Winterberg, Mavuto Mukaka, Pimnara Peerawaranun, Pasathorn Sirithiranont, Zoe Doran, Christian F. Ockenhouse, Karen Ivinson, Cynthia Lee, Ashley J. Birkett, David C. Kaslow, Pratap Singhasivanon, Nicholas P.J. Day, Arjen M. Dondorp, Nicholas J. White, Sasithon Pukrittayakamee   +21 more
doaj   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Hematological aspects in malaria

Medical Journal of Dr. D.Y. Patil University, 2013
Background: Malaria is a major health problem at the global level. In Indian subcontinent, it is a major cause of mortality in immunosuppressed patients and in extreme ages of life.
Pradhan M Pagaro, Pradeep Jadhav
doaj   +1 more source

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum. [PDF]

, 2015
BackgroundA vaccine that interrupts malaria transmission (VIMT) would be a valuable tool for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and mosquito stage antigens of the malaria parasite that induce immune ...
Abebe, Yonas, Billingsley, Peter F, Eappen, Abraham G, Hoffman, Stephen L, Li, Minglin, Li, Tao, Padilla, Debbie, Richman, Adam M, Rodriguez-Barraquer, Isabel, Sim, B Kim Lee   +9 more
core   +1 more source