Results 41 to 50 of about 24,188,006 (246)

Similar Prevalence of Plasmodium falciparum and Non–P. falciparum Malaria Infections among Schoolchildren, Tanzania

Emerging Infectious Diseases, 2023
Achieving malaria elimination requires considering both Plasmodium falciparum and non–P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp.
Rachel Sendor, Cedar L. Mitchell, Frank Chacky, Ally Mohamed, Lwidiko E. Mhamilawa, Fabrizio Molteni, Ssanyu Nyinondi, Bilali Kabula, Humphrey Mkali, Erik J. Reaves, Naomi Serbantez, Chonge Kitojo, Twilumba Makene, Thwai Kyaw, Meredith Muller, Alexis Mwanza, Erin L. Eckert, Jonathan B. Parr, Jessica T. Lin, Jonathan J. Juliano, Billy Ngasala   +20 more
doaj   +1 more source

Plasmodium falciparum accompanied the human expansion out of Africa [PDF]

, 2010
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection [1-3].
Nakamura, M., Manica, A., Sawai, H., Kaneko, A., Escalante, A.A., Horii, T., Sakihama, N., Björkman, A., Färnert, A., Mita, T., Jombart, T., Ferreira, M.U., Horibe, S., Prugnolle, F., Palacpac, N., Tanabe, K., Kishino, H., Ohmae, H., Eriksson, A., Ranford-Cartwright, L.C., Balloux, F.   +20 more
core   +2 more sources

Plasmodium falciparum population structure inferred by msp1 amplicon sequencing of parasites collected from febrile patients in Kenya

Malaria Journal, 2023
Background Multiplicity of infection (MOI) is an important measure of Plasmodium falciparum diversity, usually derived from the highly polymorphic genes, such as msp1, msp2 and glurp as well as microsatellites.
Brian Andika, Victor Mobegi, Kimita Gathii, Josphat Nyataya, Naomi Maina, George Awinda, Beth Mutai, John Waitumbi   +7 more
doaj   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate [PDF]

, 2007
Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria.
Steen, Katie E, Bull, PC, Warimwe, G, Arman, M, Raza, Ahmed, Bull, Peter, Havlik, I, Steen, KE, Arman, Monica, Rowe, J Alexandra; id_orcid, Kyriacou, HM, Warimwe, George, Havlik, Ivan, Kyriacou, Helen M, Bull, Peter C, Raza, A, Rowe, JA   +16 more
core   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi [PDF]

, 2011
<b>Background:</b> Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P.
McConnachie Alex, Bruce Marian C, Alex McConnachie, Bruce, M.C., McConnachie, A., Malcolm E Molyneux, Molyneux, M.E., Macheso Allan, Allan Macheso, Macheso, A., Marian C Bruce, Molyneux Malcolm E   +11 more
core   +1 more source

The genetic landscape of origins of replication in P. falciparum. [PDF]

Nucleic Acids Res, 2023
Abstract Various origin mapping approaches have enabled genome-wide identification of origins of replication (ORI) in model organisms, but only a few studies have focused on divergent organisms. By employing three complementary approaches we provide a high-resolution map of ORIs in Plasmodium falciparum, the deadliest human malaria ...
Castellano CM, Lacroix L, Mathis E, Prorok P, Hennion M, Lopez-Rubio JJ, Méchali M, Gomes AR.   +7 more
europepmc   +4 more sources

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source