Results 41 to 50 of about 145,240 (241)

Late dihydroartemisinin-piperaquine treatment failure of P. falciparum malaria attack related to insufficient dosing in an obese patient

IDCases, 2023
We report the case of an obese patient who experienced late failure on day28 of a well-conducted treatment with artesunate, followed by dihydroartemisinin-piperaquine (DHA-PPQ) for a severe P. falciparum malaria attack. The same P.
M. Parisey, S. Houze, J. Bailly, N. Taudon, K. Jaffal, N. Argy, C. Rouzaud, B. Mégarbane, S. Lariven, Y. Yazdanpanah, S. Matheron   +10 more
doaj   +1 more source

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model [PDF]

, 2016
Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies.
Baro, Nicholas, Buckee, Caroline, Childs, Lauren M., Daniels, Rachel, Dow, Geoffrey S., Duraisingh, Manoj T., Gerena, Lucia, Kyle, Dennis, Mantel, Pierre-Yves, Marti, Matthias, Mukherjee, Angana, Obaldía III, Nicanor, Otero, William, Volkman, Sarah K., Wirth, Dyann F.   +14 more
core   +1 more source

Plasmodium falciparum population structure inferred by msp1 amplicon sequencing of parasites collected from febrile patients in Kenya

Malaria Journal, 2023
Background Multiplicity of infection (MOI) is an important measure of Plasmodium falciparum diversity, usually derived from the highly polymorphic genes, such as msp1, msp2 and glurp as well as microsatellites.
Brian Andika, Victor Mobegi, Kimita Gathii, Josphat Nyataya, Naomi Maina, George Awinda, Beth Mutai, John Waitumbi   +7 more
doaj   +1 more source

DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]

, 2014
BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M, Gill, Sarjeet S, Le Roch, Karine G, Lonardi, Stefano, Polishko, Anton, Ponts, Nadia, Prudhomme, Jacques   +6 more
core   +3 more sources

Similar Prevalence of Plasmodium falciparum and Non–P. falciparum Malaria Infections among Schoolchildren, Tanzania

Emerging Infectious Diseases, 2023
Achieving malaria elimination requires considering both Plasmodium falciparum and non–P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp.
Rachel Sendor, Cedar L. Mitchell, Frank Chacky, Ally Mohamed, Lwidiko E. Mhamilawa, Fabrizio Molteni, Ssanyu Nyinondi, Bilali Kabula, Humphrey Mkali, Erik J. Reaves, Naomi Serbantez, Chonge Kitojo, Twilumba Makene, Thwai Kyaw, Meredith Muller, Alexis Mwanza, Erin L. Eckert, Jonathan B. Parr, Jessica T. Lin, Jonathan J. Juliano, Billy Ngasala   +20 more
doaj   +1 more source

Evaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia. [PDF]

, 2006
The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P.
Angarita, B, Counihan, H, Gordillo, F, Guthmann, J P, Hamade, P, Hill, O, van den Broek, I   +6 more
core   +1 more source

PlasmoID: A P. falciparum Information Discovery Tool

In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation, 2009
Plasmodium falciparum is the parasite responsible for more than 90% of deaths that occur due to malaria. Organization and mining of 'omic' (genomic, proteomic, transcriptomic, interactomic) data can improve our understanding of P. falciparum biology and help in the fight against malaria.
Aditya Rao, Sri Jyothsna Yeleswarapu, Gudladona Raghavendra, Rajgopal Srinivasan, Gopalakrishnan Bulusu   +4 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters [PDF]

, 2016
The glucose transporter PfHT is essential to the survival of the malaria parasite Plasmodium falciparum and has been shown to be a druggable target with high potential for pharmacological intervention.
Autry, Joseph M, Edwards, Rachel L, Heitmeier, Monique R, Hruz, Paul W, Ilagan, Ma Xenia G, Kraft, Thomas E, Odom, Audrey R, Payne, Maria A, Putanko, Marina, Thomas, David D   +9 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source