Results 71 to 80 of about 66,832 (203)
Suboptimal Prophylaxis for P. falciparum [PDF]
Van den Ende, J. +2 more
openaire +2 more sources
Insectary‐reared mosquitoes were simultaneously assessed for species identification, bloodmeal source analysis and Plasmodium detection, using a single multiplexed sequencing run on the MinION sequencing platform. The method was applied to 150 insectary‐reared mosquitoes, representing nine species blood‐fed with five vertebrate hosts and 40 samples for
E. Abby Rogers +5 more
wiley +1 more source
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig +14 more
wiley +1 more source
Efek Pemberian ?-Mangostin dari Garcinia tetranda Pierre Terhadap Morfologi P.falciparum
Morphological changes assay to P. falciparum from the effects of α-mangostin from G. tetranda using TEM methods has been done. This test aims to determine the effect of mangostin on P.
Hadi Kuncoro
doaj +1 more source
Actinomycin Derivatives: Structural Diversification and Biological Activities
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
Objective: This study was designed to assess the frequency of malaria infection in human population Duki, Harnai and Sibi the hottest areas of centre Balochistan, Pakistan. Study Design: A descriptive study.
Mohammad Iqbal Yasinzai +1 more
doaj +2 more sources
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite +10 more
wiley +1 more source
A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova +4 more
wiley +1 more source
The power of many: when genetics met yeasts and high‐throughput
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Serum enzymes activities in Plasmodium falciparum infection in Southern Pakistan [PDF]
Objective: Serum levels of lactate dehydrogenase (LDH),aspartate aminotranferase (AST), alanine aminotransferase(ALT), and alkaline phosphatase (ALP) were assessed todetermine the liver functions of patients infected withPlasmodium falciparum. The enzyme
Koay Yen Chin +3 more
doaj

