Results 71 to 80 of about 24,188,006 (246)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Unfolding the Genome: The Case Study of P. falciparum [PDF]

The International Journal of Biostatistics, 2018
Abstract The development of new ways to probe samples for the three-dimensional (3D) structure of DNA paves the way for in depth and systematic analyses of the genome architecture. 3C-like methods coupled with high-throughput sequencing can now assess physical interactions between pairs of loci in a genome-wide fashion, thus enabling ...
openaire   +3 more sources

Plasmodium falciparum infection and clinical indicators in relation to net coverage in central Côte d'Ivoire [PDF]

, 2014
Sleeping under a net, particularly a long-lasting insecticidal net (LLIN), is associated with reduced malaria morbidity and mortality, but requires high coverage and adherence.
Ouattara, Allassane F., Dagnogo, Mamadou, Raso, Giovanna, Olliaro, Piero L., Utzinger, Jürg, Koudou, Benjamin G., Tanner, Marcel   +6 more
core   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

The dynamics of natural Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Natural immunity to Plasmodium falciparum has been widely studied, but its effects on parasite dynamics are poorly understood. Acquisition and clearance rates of untreated infections are key elements of the dynamics of malaria, but estimating
Ingrid Felger (92160), Beck, Hans-Peter, Sama, W., Beck, H. P., Tiaden, A., Hans-Peter Beck, Bretscher, M., Nicole Falk (134915), Owusu-Agyei, Seth, Beck Hans-Peter, Felger Ingrid, Felger, Ingrid, Sama, Wilson, Sama Wilson, Maire, Martin, Tiaden, André, Ingrid Felger, Falk, Nicole, Wilson Sama (134920), Thomas A. Smith (95630), Wilson Sama, Bretscher, Michael T, André Tiaden, Seth Owusu-Agyei (80063), Tiaden André, Bretscher Michael T., Owusu-Agyei, S., Felger, I., Seth Owusu-Agyei, Owusu-Agyei Seth, Smith, T. A., Hans-Peter Beck (129757), Maire Martin, Martin Maire (134910), André Tiaden (134918), Michael T Bretscher, Michael T. Bretscher (134912), Falk Nicole, Martin Maire, Smith, Thomas A, Thomas A Smith, Falk, N., Maire, N., Nicole Falk, Smith Thomas A.   +44 more
core   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. [PDF]

, 2012
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.
Yeang, Chhiang, Shunmay Yeung, Nguon, Sokomar, Chea, Nguon, Thomson Andrew, Chhiang Yeang (130756), Steven Bjorge (130709), Khim Nimol, Samphornarann Top (130727), Habib, Najibullah, Robert D Newman, Andrew Thomson (23309), Menard, Didier, Sovann Yok, Kim Saorin, Kim, Saorin, Sophal, Uth, Bjorge Steven, Benoit Witkowski, Didier Menard (2577220), Najibullah Habib, Michelle M Thompson, Steven Bjorge, Sarorn Sum, Didier Menard, Nimol Khim (130700), Andrew Thomson, Christophel Eva-Maria, Ros, Seyha, Mellor Steve, Top Samphornarann, Hoyer Stefan, Bjorge, Steven, Socheat Duong, Saorin Kim, Menard Didier, Kheng, Sim, Nguon Chea, Hoyer, Stefan, Top, Samphornarann, Sokomar Nguon, Najibullah Habib (130696), Thompson Michelle M., Robert D. Newman (130763), Sarorn Sum (130703), Sophal Uth, Witkowski Benoit, Witkowski, Benoit, Sovann Yok (130723), Socheat Duong (130761), Newman, Robert D, Nguon Sokomar, Uth Sophal, Michelle M. Thompson, Michelle M. Thompson (130739), Duong, Socheat, Kheng Sim, Seyha Ros (130731), Mellor, Steve, Yeung, Shunmay, Chhiang Yeang, Ariey Frédéric, Seyha Ros, Samphornarann Top, Saorin Kim (130692), Christophel, Eva-Maria, Khim, Nimol, Steve Mellor, Sim Kheng (130715), Uth Sophal (130734), Chea Nguon, Eva-Maria Christophel, Nguon Chea (130719), Yok Sovann, Frédéric Ariey (92228), Ros Seyha, Sum, Sarorn, Nimol Khim, Thomson, Andrew, Frédéric Ariey, Yeang Chhiang, Newman Robert D., Sum Sarorn, Thompson, Michelle M, Habib Najibullah, Ariey, Frédéric, Duong Socheat, Yeung Shunmay, Eva-Maria Christophel (130705), Sim Kheng, Sokomar Nguon (130689), Stefan Hoyer (130687), Stefan Hoyer, Yok, Sovann, Robert D. Newman, Steve Mellor (130744), Benoit Witkowski (130751), Shunmay Yeung (53391)   +97 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

HbS Protection from P. falciparum Infection

British Journal of Medicine and Medical Research, 2013
Recent investigations have highlighted various mechanisms of interaction between the Plasmodium falciparum (P. falciparum) parasite and the host, which are important for the understanding of the well-known protective effect by haemoglobinopathies like Sickle Cell Trait and α-Thalassemia against incidence and severity of malaria.
openaire   +1 more source