Results 71 to 80 of about 20,281 (179)

Auditory Neuropathy: Challenges and Significant Progress in Diagnosis and Treatment

Advanced Therapeutics, Volume 9, Issue 3, March 2026.
Auditory neuropathy is a complex disorder that causes sensorineural hearing impairment in patients. Recently, breakthrough progress has been made in the gene therapy of auditory neuropathy. This review focuses on auditory neuropathy, covering its pathophysiology, etiology, epidemiology, clinical manifestations, diagnostic techniques, treatment ...
Wen Xie, Ling Lu, Busheng Tong, Lian Fang, Qingqing Dai, Xiaowan Chen, Jieyu Qi, Xiaoyun Qian, Xia Gao, Renjie Chai, Jun Yang, Maoli Duan   +11 more
wiley   +1 more source

A Case of Knobloch Syndrome With Lens Dislocation Resembling Homocystinuria

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT We report a 39‐year‐old woman with lifelong visual impairment who presented in June 2024 with progressive visual deterioration in her right eye. Ophthalmologic evaluation revealed severe high myopia, vitreoretinal degeneration, phthisis bulbi of the left eye, and downward lens dislocation of the right eye.
Elnaz Asadollahzadeh, Ali Rezaei, Vahid Shahmaei, Mohammad‐Sadegh Johari, Mohammad Ali Sahraian   +4 more
wiley   +1 more source

Update of the P100-1 Concrete Provisions [PDF]

Mathematical Modelling in Civil Engineering, 2014
Abstract In an effort to improve the harmonization of the Romanian design codes with the Eurocodes, the revision of the Seismic Design Code, P100-1, started in April 2010 and ended in September 2013. The main issues addressed during the revision process are presented in this paper.
openaire   +1 more source

Therapeutic targeting of MALT1 in oncology: Mechanism, inhibitor development, and clinical prospects

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract MALT1, a multifunctional protease molecule, plays a pivotal role in the adaptive immunity by regulating immune cell survival, proliferation and activation through the nuclear transcription factor‐κB (NF‐κB) signaling pathway by scaffold and protease activities.
Xintao Cao, Peixia Wang, Yuan Ji, Yongliang Sun, Dejiu Zhang   +4 more
wiley   +1 more source

Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100

Mediators of Inflammation, 2015
We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor.
Víctor Toledano, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Marta Flandez, Enrique Álvarez, Aníbal Varela-Serrano, Ramón Cantero, Gema Valles, Francisco García-Rio, Eduardo López-Collazo   +9 more
doaj   +1 more source

Insights into Api m 10‐Isoforms and Splice Variants: More Than One Major IgE‐Binding Epitope

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
The structural, clinical and preclinical insights into Api m 10 and its immunodominant epitopes gained in this study provide substantial insights for the future development of active and passive VIT as well as further treatment approaches. ABSTRACT Background Honey bee venom (HBV) often triggers severe IgE‐mediated allergies.
Kathrin Elisabeth Paulus‐Tremel, Michelle Beatrice Wolff, Natalija Novak, Nicola Wagner, Alisa Landgraf, Stefan Schülke, Thomas Holzhauser, Vera Mahler   +7 more
wiley   +1 more source

p100 Deficiency is insufficient for full activation of the alternative NF-κB pathway: TNF cooperates with p52-RelB in target gene transcription.

PLoS ONE, 2012
BackgroundConstitutive activation of the alternative NF-κB pathway leads to marginal zone B cell expansion and disorganized spleen microarchitecture. Furthermore, uncontrolled alternative NF-κB signaling may result in the development and progression of ...
Agnes Lovas, Anja Weidemann, Daniela Albrecht, Lars Wiechert, Debra Weih, Falk Weih   +5 more
doaj   +1 more source

The effects of bromazepam on the early stage of visual information processing (P100) Efeitos do bromazepam no estágio inicial do processamento de informação visual (P100)

Arquivos de Neuro-Psiquiatria, 2007
The early stages of visual information processing, involving the detection and perception of simple visual stimuli, have been demonstrated to be sensitive to psychotropic agents.
Fernanda Puga, Isabel Sampaio, Heloisa Veiga, Camila Ferreira, Maurício Cagy, Roberto Piedade, Pedro Ribeiro   +6 more
doaj   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

Pattern Visual Evoked Potential Changes in Diabetic Patients without Retinopathy

Journal of Ophthalmology, 2017
Purpose. To assess the different check sizes of pattern visual evoked potential (PVEP) in diabetic patients without retinopathy according to HbA1c levels and diabetes duration. Methods.
Ozgur Balta, Gulten Sungur, Mehmet Yakin, Nurten Unlu, Oyku Bezen Balta, Firdevs Ornek   +5 more
doaj   +1 more source