Results 241 to 250 of about 89,060 (300)

The Australian Penile Cancer Clinical Registry: a comprehensive national approach to data collection

BJU International, EarlyView.
Background Penile cancer is a rare malignancy, with an Australian incidence of 0.6 in 100 000 men, with a wide range of clinical presentations, from localised, curable tumours to aggressive forms with high morbidity and mortality. Epidemiological data and management guidelines for penile cancer in Australia are limited.
Henry Y.C. Pan, David Homewood, Harrison Lucas, Brendan Dittmer, Jiasian Teh, Jonathan S. O'Brien, Jianliang Liu, Ben Tran, Justin Chee, James A. Churchill, Nathan Lawrentschuk, Niall M. Corcoran   +11 more
wiley   +1 more source

Comparative Clinicopathological Features and p16 Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Cervix: A Single-Center Retrospective Cohort Study in Saudi Arabia (2020-2024). [PDF]

Biomedicines
Alqassim E, Abu Alola MJ, Alqassim AY, Tulbah A, Alawami S, Samman A, Azzouni ZY, Shubayli AA, Al-Qahtani AA, Alahmari AA, Alhamlan F, Al-Qahtani AA.   +11 more
europepmc   +1 more source

Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the App^NL-G-F Mouse Model of Alzheimer's Disease. [PDF]

Aging Cell
Sweeney EM, Abate G, Bakker BRV, Mastinu A, Lai Y, Uberti D, Nilsson P, Tambaro S.   +7 more
europepmc   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Cost-effectiveness of Including p16/Ki-67 Dual Staining in the Detection of Cervical Lesions in Colombia, 2024 [PDF]

Rev Colomb Obstet Ginecol
Álvarez A, Díaz S, Niño RA, Medina YA, Chacón A, Franco A.   +5 more
europepmc   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

p53 Positivity Predicts Poor Survival in Oropharyngeal Squamous Cell Carcinoma Dependent on HPV Status. [PDF]

Cancers (Basel)
de Oliveira LQR, Farshadi F, Mlynarek A, Mascarella MA, Hier M, Coletta RD, Wurzba SDS.   +6 more
europepmc   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging. [PDF]

Aging Cell
Shvedova M, Thanapaul RJRS, Wang Q, Shin GH, Dhillon J, Roh DS.   +5 more
europepmc   +1 more source

Characteristics of Emotional Support Provided by Adolescent Young Carers: A Qualitative Exploratory Study

Child &Family Social Work, EarlyView.
ABSTRACT Adolescent young carers (AYCs), aged 12–17, provide regular, unpaid support to a family member with a chronic illness or disability. Among the various forms of help they provide, emotional support (ES) plays a central role—demanding strong emotional and psychological investment yet remaining underexplored during adolescence, a period of ...
Céline Lacombe, Julie Glatz, Aurélie Untas   +2 more
wiley   +1 more source