Results 1 to 10 of about 46,467 (169)

Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer [PDF]

Obstetrics & Gynecology Science, 2020
Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present study, we evaluated the p16 and p53 gene expressions of stage 1a
Emre Günakan, Yusuf Aytaç Tohma, Latife Atasoy Karakaş, Hüseyin Akıllı, Asuman Nihan Haberal, Ali Ayhan   +5 more
doaj   +1 more source

Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]

Clinical and Molecular Hepatology, 2020
Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa, Mohammed Hassan Saiem Al-Dahr, Dalia Abdel Hamid Omran, Zeinab Fathy Abdullah, Suzan Hamdy Elmasry, Mohamed Nabil Ibrahim   +5 more
doaj   +1 more source

Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration

Journal of Orthopaedic Surgery and Research, 2022
Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai, Xiao Ma, Huihui Guo, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng   +6 more
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The relationship between P16 INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand

Scientific Reports, 2022
DNA methylation can regulate the expression of tumour suppressor genes P16 and TP53, environmental factors, which are both important factors related to an increased risk and prognosis of oesophageal cancer (EC). However, the association between these two
Arisara Poosari, Thitima Nutravong, Wises Namwat, Wiphawan Wasenang, Prakasit Sa-ngiamwibool, Piti Ungareewittaya   +5 more
doaj   +1 more source

The CDKN2A (p16) Gene and Human Cancer [PDF]

Molecular Medicine, 1997
CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome.
Foulkes, William D., Flanders, Tamar Y., Pollock, Pamela M., Hayward, Nicholas K.   +3 more
openaire   +2 more sources

Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation [PDF]

Chinese Journal of Cancer Research, 2018
To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Publicly available database of Cancer Cell Line Encyclopedia (CCLE) was used in bioinformatic analyses. Methylation of CpG islands was detected by denaturing high performance liquid chromatography (DHPLC).
Ying, Gan, Wanru, Ma, Xiuhong, Wang, Juanli, Qiao, Baozhen, Zhang, Chenghua, Cui, Zhaojun, Liu, Dajun, Deng   +7 more
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Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. [PDF]

PLoS ONE, 2011
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are ...
Josette M Douville, David Y C Cheung, Krista L Herbert, Teri Moffatt, Jeffrey T Wigle   +4 more
doaj   +1 more source

The expression of steroidogenic genes in ovine corpus luteum during early pregnancy [PDF]

Eurasian Journal of Veterinary Sciences, 2021
Aim: The goal of this study was to investigate the expression of steroidogenic genes in ovine corpus luteum during early pregnancy. Materials and Methods: The animal model was designed as pregnancy; ewes were divided into three sub-groups, pregnancy 12th
Mustafa Hitit, Mehmet Köse, Bülent Bülbül, Nadir Koçak, Mehmet Osman Atlı   +4 more
doaj  

p16 Gene Expression in Basal Cell Carcinoma [PDF]

Archives of Medical Research, 2008
Basal cell carcinoma (BCC) develops predominantly in sun-exposed skin in fair-skinned individuals prone to sunburn. BCC typically occurs in adults. High exposure to ultraviolet (UV) radiation increases rate of developing BCC, a slowly growing tumor that occurs in hair-growing squamous epithelium and rarely metastasizes. In genetic studies, BCC patients
Eshkoor, Sima Atoallahi, Ismail, Patimah, Abdul Rahman, Sabariah, Oshkour, Soraya Ataollahi   +3 more
openaire   +2 more sources

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).

PLoS ONE, 2020
Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from ...
Nabil F Saba, Ashok R Dinasarapu, Kelly R Magliocca, Bhakti Dwivedi, Sandra Seby, Zhaohui S Qin, Mihir Patel, Christopher C Griffith, Xu Wang, Mark El-Deiry, Conor Ernst Steuer, Jeanne Kowalski, Dong Moon Shin, Michael E Zwick, Zhuo Georgia Chen   +14 more
doaj   +1 more source