Results 1 to 10 of about 47,345 (308)
Hypermethylation of the p16 Gene and Lack of p16 Expression in Hepatoblastoma [PDF]
Modern Pathology, 2003 Hepatoblastoma is the most frequent pediatric liver tumor that develops mostly in young children. Abnormal regulation of cell cycle regulatory genes including p16 has been described, displaying no p16 mRNA and p16 protein in hepatoblastomas. The inactivation of p16, leading to the disruption of cell cycle control is involved in many types of human ...
Ja-June Jang, Eunsil Yu, Kim Jung Sun
exaly +3 more sources
Epigenetic Changes in Tumor Suppressor Genes, P15, P16, APC-3 and E-cadherin in Body Fluid
Kaohsiung Journal of Medical Sciences, 2007 The inactivation of tumor suppressor genes by promoter methylation plays an important role in the development of cancers; it can also be used as a marker to distinguish cancerous cells from non-cancer cells.
Mei-Ling Chen +4 more
doaj +2 more sources
Methylation status of p16 and p14 genes in locally advanced rectal cancer: Potential clinical implication [PDF]
Archives of Biological Sciences, 2018 Methylation of p16 and p14 genes is a common event in colorectal cancers; however, their exact role in the prediction of patients’ outcome is unclear. We conducted this retrospective study to evaluate their potential predictive and/or prognostic roles ...
Kožik Bojana +6 more
doaj +3 more sources
Neoplasia: An International Journal for Oncology Research, 2006 Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis.
Yang Liu +4 more
doaj +2 more sources
Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim +4 more
doaj +3 more sources
Journal of Pure and Applied Microbiology, 2019 Oral carcinogenesis is a multi-step process, affecting predominantly elderly males with a long history of smoking and alcohol drinking while the role of infectious agents in its progression has not been fully identified.
Hayat Ghaith Sachit +4 more
doaj +2 more sources
Clinical and Applied Thrombosis/HemostasisObjective DNA methylation, as an epigenetic alteration, plays an essential role in the development of atherosclerosis and venous thrombosis. E-cadherin, a tumor suppressor gene and adhesion molecule, has a crucial function in platelet aggregation and ...
Niloofar Abak M.Sc +5 more
doaj +2 more sources
Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2020 Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present study, we evaluated the p16 and p53 gene expressions of stage 1a
Emre Günakan +5 more
doaj +1 more source
Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]
Clinical and Molecular Hepatology, 2020 Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa +5 more
doaj +1 more source
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
Journal of Orthopaedic Surgery and Research, 2022 Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai +6 more
doaj +1 more source