Results 31 to 40 of about 5,499,505 (307)
Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. [PDF]
PLoS ONE, 2013 Breast cancer is one of the most lethal diseases in women; however, the precise etiological factors are still not clear. Genistein (GE), a natural isoflavone found in soybean products, is believed to be a potent chemopreventive agent for breast cancer ...
Yuanyuan Li +3 more
doaj +1 more source
Oncology Report, 2016 5-Aza-2′-deoxycytidine (5-Aza-CdR) is currently acknowledged as a demethylation drug, and causes a certain degree of demethylation in a variety of cancer cells, including pancreatic cancer cells.
Feng-Ping Pan +13 more
semanticscholar +1 more source
Methylation status of p16 and p14 genes in locally advanced rectal cancer: Potential clinical implication [PDF]
Archives of Biological Sciences, 2018 Methylation of p16 and p14 genes is a common event in colorectal cancers; however, their exact role in the prediction of patients’ outcome is unclear. We conducted this retrospective study to evaluate their potential predictive and/or prognostic roles ...
Kožik Bojana +6 more
doaj +1 more source
Translational Oncology, 2009 BACKGROUND Aberrant DNA methylation has been recognized in human breast carcinogenesis as a common molecular alteration associated with the loss of expression of a number of key regulatory genes.
Mohammad Raish +10 more
semanticscholar +1 more source
Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim +4 more
doaj +1 more source
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
PLoS ONE, 2011 BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer.
Huda H Al-Khalaf +8 more
doaj +1 more source
Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. [PDF]
PLoS ONE, 2014 Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV).
Inga Hinrichsen +6 more
doaj +1 more source
The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology
Biology and Life Sciences Forum, 2023 P16INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. In development, a potential role of p21 and of p19ARF has been postulated, but little is known about p16. Our previous results revealed a highly dynamic
Hasan Safwan-Zaiter +2 more
doaj +1 more source
Increased Radiosensitivity of p16 Gene‐deleted Human Glioma Cells after Transfection with Wild‐type p16 Gene [PDF]
Japanese Journal of Cancer Research, 1997 The A1235 and T98 cell lines derived from human gliomas have homozygous deletions in their p16 genes and are radiosensitive and radioresistant, respectively, with respect to other established glioma cell lines. These differences in radiosensitivity may be due to variations to some extent among cell lines, rather than genetically defined resistance or ...
Miyakoshi, Junji +5 more
openaire +2 more sources
Scientific Reports, 2023 Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with ASCC. Forty-one patients diagnosed with ASCC
Takahiko Ito +14 more
doaj +1 more source