Results 51 to 60 of about 46,467 (169)

Relationship between inactivation of p16 gene and gastric carcinoma

World Journal of Gastroenterology, 2003
To investigate the relationship between inactivation of p16 gene and gastric carcinoma, and the mechanism of inactivation of p16 gene in gastric carcinogenesis.40 fresh tumor tissue specimens were taken from primary gastric cancer patients. Expression of P16 protein was detected by immunohistochemical method.
Guo-Hai, Zhao, Tie-Chen, Li, Liang-Hui, Shi, Ya-Bin, Xia, Lin-Ming, Lu, Wen-Bin, Huang, Hui-Lan, Sun, Yi-Sheng, Zhang   +7 more
openaire   +2 more sources

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

BMC Cancer, 2009
Background Several genetic alterations have been demonstrated to contribute to the development and progression of melanoma. In this study, we further investigated the impact of key-regulator genes in susceptibility and pathogenesis of such a disease ...
Canzanella Sergio, Stanganelli Ignazio, Pagani Elena, Ascierto Paolo A, Caracò Corrado, Budroni Mario, Cossu Antonio, Muggiano Antonio, Casula Milena, Sini MariaCristina, Palomba Grazia, Palmieri Giuseppe   +11 more
doaj   +1 more source

DNA Methylation Pattern and mRNA Expression Level of E-Cadherin and P16 Genes in Thrombotic Disorders

Clinical and Applied Thrombosis/Hemostasis
Objective DNA methylation, as an epigenetic alteration, plays an essential role in the development of atherosclerosis and venous thrombosis. E-cadherin, a tumor suppressor gene and adhesion molecule, has a crucial function in platelet aggregation and ...
Niloofar Abak M.Sc, Mehdi Azad Ph.D, Fatemeh Mohammad Ali Ph.D, Mostafa Saberian Ph.D, Saeed Turkaman M.Sc, Shaban Alizadeh Prof   +5 more
doaj   +1 more source

Assessing the Diagnostic Accuracy of Salivary Biomarkers in Detecting Oral Squamous Cell Carcinoma

Journal of Pharmacy and Bioallied Sciences
Background: Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.
Priyanka Vinod Bansal, Liza Mohanty, Chinmay Raval, Inderjit M. Gowdar, Anshul Chopra, Bharti Gupta, Ramanpal S. Makkad   +6 more
doaj   +1 more source

[Inactivation of CDKN2A gene (p16) in gallbladder carcinoma].

Revista medica de Chile, 2004
132
Roa, JC, Vo, Q, Araya, JC, Villaseca, M, Guzman, P, Ibacache, G, de Aretxabala, X, Roa, I   +7 more
openaire   +3 more sources

Aberrant promoter hypermethylation of p16 gene in endometrial carcinoma

Tumor Biology, 2015
Previous studies demonstrated that the loss of function of the p16INK4A gene is mainly caused by the hypermethylation of p16 gene promoter; however, whether or not it is associated with the incidence of endometrial carcinoma (EC) remains unclear.
Zhuo-ying, Hu, Liang-dan, Tang, Qin, Zhou, Lin, Xiao, Yi, Cao   +4 more
openaire   +2 more sources

Carcinoma gástrico e gastrite crónica: regulação epigenética por metilação dos genes CDH1 (Caderina-E), CDKN2A (p16INK4A), PTGS2 (COX2) e EGFR.

Acta Médica Portuguesa, 2010
The genetic and epigenetic alterations are being studied as one of the causes of gastric cancer (GC) progression and development. DNA methylation is an epigenetic alteration which leads to suppressor gene silencing and proto-oncogene activation, playing ...
Maria Silva, Diana Azenha, César Pereira, Anabela Almeida, Sandra Balseiro, Ana Maria Sampaio, Paulo Santos, Lina Carvalho   +7 more
doaj   +1 more source

Detection of High-Risk Human Papillomavirus in Oral Cavity Squamous Cell Carcinoma Using Multiple Analytes and Their Role in Patient Survival

Journal of Global Oncology, 2018
Purpose: Accurate detection of human papillomavirus (HPV) in oral cavity squamous cell carcinoma (OSCC) is essential to understanding the role of HPV in disease prognosis and management of patients.
Vinayak Palve, Jamir Bagwan, Neeraja M. Krishnan, Manisha Pareek, Udita Chandola, Amritha Suresh, Gangotri Siddappa, Bonney L. James, Vikram Kekatpure, Moni Abraham Kuriakose, Binay Panda   +10 more
doaj   +1 more source

Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells

European Journal of Medical Research
Artesunate (ART), an effective antimalarial semisynthetic derivative of artemisinin, exhibits antitumour properties, but the mechanism(s) involved remain elusive.
Linlin Mao, Guodong Deng, Mengfan Li, Shih-Hsin Lu, Wei Jiang, Xiying Yu   +5 more
doaj   +1 more source

Helicobacter pylori Eradication Modulates Aberrant CpG Island Hypermethylation in Gastric Carcinogenesis

The Korean Journal of Gastroenterology, 2016
Background : /Aims: Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. We evaluated the long-term effect of H. pylori eradication on promotor CpG island hypermethylation in gastric carcinogenesis. Methods : : H.
Jeongmin Choi, Sang Gyun Kim, Byeong Gwan Kim, Seong-Joon Koh, Ji Won Kim, Kook Lae Lee   +5 more
doaj   +1 more source