Results 11 to 20 of about 5,499,505 (307)
Hypermethylation of the p16 Gene and Lack of p16 Expression in Hepatoblastoma [PDF]
Modern Pathology, 2003 Hepatoblastoma is the most frequent pediatric liver tumor that develops mostly in young children. Abnormal regulation of cell cycle regulatory genes including p16 has been described, displaying no p16 mRNA and p16 protein in hepatoblastomas. The inactivation of p16, leading to the disruption of cell cycle control is involved in many types of human ...
Eunsil Yu, Ja-June Jang, Jang Ja-June
exaly +3 more sources
Neoplasia: An International Journal for Oncology Research, 2006 Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis.
Yang Liu +4 more
doaj +2 more sources
Alteration of p16 and p15 genes in human uterine tumours [PDF]
British Journal of Cancer, 1999 The roles of the p16 and p15 inhibitor of cyclin-dependent kinase tumour suppressor genes were examined in human uterine cervical and endometrial cancers. p16 mRNA, examined by reverse transcription polymerase chain reaction (RT-PCR), was significantly reduced in five of 19 (26%) cervical and four of 25 (16%) endometrial tumours.
Nakashima, R +11 more
openaire +3 more sources
Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma [PDF]
Blood, 1997 Abstract Both p16 and p15, encoded by the genes located on chromosome 9p21, are inhibitors of cyclin-dependent kinases (CDK4/6) and the upstream regulators of Rb function. In hematopoietic malignancies, deletion of p16/p15 locus has been shown to be highly specific to lymphoid, and more particularly from B-lineage malignancies except ...
M H, Ng +5 more
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Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2020 Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present study, we evaluated the p16 and p53 gene expressions of stage 1a
Emre Günakan +5 more
doaj +1 more source
Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]
Clinical and Molecular Hepatology, 2020 Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa +5 more
doaj +1 more source
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
Journal of Orthopaedic Surgery and Research, 2022 Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai +6 more
doaj +1 more source
Cancers, 2023 Simple Summary Loss of the CDKN2A gene and its protein p16 is a common event in pleural mesothelioma, which is frequently investigated to confirm the diagnosis.
B. Vrugt +8 more
semanticscholar +1 more source
Scientific Reports, 2022 DNA methylation can regulate the expression of tumour suppressor genes P16 and TP53, environmental factors, which are both important factors related to an increased risk and prognosis of oesophageal cancer (EC). However, the association between these two
Arisara Poosari +5 more
doaj +1 more source
The CDKN2A (p16) Gene and Human Cancer [PDF]
Molecular Medicine, 1997 CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome.
Foulkes, William D. +3 more
openaire +2 more sources