DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]
, 2014 Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B. +8 more
core +1 more source
Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. [PDF]
PLoS ONE, 2013 Breast cancer is one of the most lethal diseases in women; however, the precise etiological factors are still not clear. Genistein (GE), a natural isoflavone found in soybean products, is believed to be a potent chemopreventive agent for breast cancer ...
Yuanyuan Li +3 more
doaj +1 more source
Cellular senescence and tumor suppressor gene p16 [PDF]
International Journal of Cancer, 2011 AbstractCellular senescence is an irreversible arrest of cell growth. Biochemical and morphological changes occur during cellular senescence, including the formation of a unique cellular morphology such as flattened cytoplasm. Function of mitochondria, endoplasmic reticulum and lysosomes are affected resulting in the inhibition of lysosomal and ...
Hani, Rayess +2 more
openaire +2 more sources
Epigenetic and genomic biomarker discovery in breast cancer [PDF]
, 2011 Breast cancer is the most common malignancy among females and the fifth most common cause of cancer death worldwide. The research for biomarker discovery for the diagnosis and prognosis of patients with breast cancer has been going on for decades ...
Radpour, Ramin
core +1 more source
Genome-wide overexpression screen identifies genes able to bypass p16-mediated senescence in melanoma [PDF]
, 2017 Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state.
Stevenson, Alexander J +13 more
core +1 more source
The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology
Biology and Life Sciences Forum, 2023 P16INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. In development, a potential role of p21 and of p19ARF has been postulated, but little is known about p16. Our previous results revealed a highly dynamic
Hasan Safwan-Zaiter +2 more
doaj +1 more source
Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. [PDF]
PLoS ONE, 2014 Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV).
Inga Hinrichsen +6 more
doaj +1 more source
Increased Radiosensitivity of p16 Gene‐deleted Human Glioma Cells after Transfection with Wild‐type p16 Gene [PDF]
Japanese Journal of Cancer Research, 1997 The A1235 and T98 cell lines derived from human gliomas have homozygous deletions in their p16 genes and are radiosensitive and radioresistant, respectively, with respect to other established glioma cell lines. These differences in radiosensitivity may be due to variations to some extent among cell lines, rather than genetically defined resistance or ...
Miyakoshi, Junji +5 more
openaire +2 more sources
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
PLoS ONE, 2011 BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer.
Huda H Al-Khalaf +8 more
doaj +1 more source
Scientific Reports, 2023 Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with ASCC. Forty-one patients diagnosed with ASCC
Takahiko Ito +14 more
doaj +1 more source