Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle [PDF]
FEBS Letters, 1995 It has been demonstrated that protein expression of p16, the inhibitor of cyclin‐dependent kinase 4 and 6, increases 4 fold at the G1/S transition when serum‐arrested cells are restimulated to logarithmic growth. We examined the cell cycle regulation of this cyclin‐dependent kinase inhibitor in cells separated according to their cell cycle phases by ...
Thomas Soucek +2 more
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Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias [PDF]
Blood, 1994 Abstract Recently, it has been shown that the homozygous deletion of the cyclin- dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene.
Seishi Ogawa +2 more
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Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. [PDF]
PLoS ONE, 2011 Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are ...
Josette M Douville +4 more
doaj +3 more sources
Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients [PDF]
British Journal of Cancer, 2015 Malignant pleural mesothelioma (MPM) is a rare and essentially incurable malignancy most often linked with occupational exposure to asbestos fibres. In common with other malignancies, the development and progression of MPM is associated with extensive dysregulation of cell cycle checkpoint proteins that modulate cell proliferation, apoptosis, DNA ...
A O'Grady, Brian J Harvey, E W Kay
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Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas [PDF]
Cancer, 1996 Chromosomal abnormalities involving band 1p32, especially deletions, are frequent in neuroblastomas, indicating that a tumor suppressor gene(s) is localized at this region. The p18 gene, one of the cyclin-dependent kinase inhibitor (CDKI) genes, maps to this chromosomal region.
Norihiko Kawamata +2 more
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Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features [PDF]
Blood, 1995 A recently described putative tumor suppressor gene, the cyclin-dependent kinase 4 inhibitor (p16), has been shown to be altered by deletions and/or point mutations in various human cancers. To assess the incidence and clinico-biologic correlations of p16 homozygous deletion in hemopoietic tumors, we studied a panel of 244 DNA samples representative of
Giuseppe Cimino, S Pisegna, G Alimena
exaly +6 more sources
Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma
Pathology - Research and Practice, 2021 Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (
Sofija Glumac +11 more
openaire +3 more sources
P16 expression in human breast carcinoma and its relationship to clinicopathological parameters
Advanced Biomedical Research, 2023 Background: p16 is a cyclin-dependent kinase inhibitor and a cardinal regulator of the cell cycle. The relationship between p16 overexpression and poor prognosis of breast cancer has been reported in some studies.
Fereshteh Mohammadizadeh, Farnaz Nasri
doaj +1 more source
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex. [PDF]
PLoS ONE, 2014 Neural precursor cells (NPCs) in the neocortex exhibit a high proliferation capacity during early embryonic development and give rise to cortical projection neurons after maturation.
Ryohei Minamide +3 more
doaj +1 more source
Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase [PDF]
Journal of Biological Chemistry, 1995 Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals.
O, Aprelikova, Y, Xiong, E T, Liu
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