Results 1 to 10 of about 5,180 (222)
Senolytics in the treatment of diabetic retinopathy
Frontiers in Pharmacology, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness.
Ashay D Bhatwadekar, Bhatwadekar Ashay D
exaly +7 more sources
Discovery of senolytics using machine learning [PDF]
Nature Communications, 2023 Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer-Barreto +10 more
doaj +7 more sources
Frontiers in Cell and Developmental Biology, 2022 Senolytics are a class of drugs that selectively eliminate senescent cells and ameliorate senescence-associated disease. Studies have demonstrated the accumulation of senescent disc cells and the production of senescence-associated secretory phenotype ...
Fangli Huang, Fuxin Wei, Yu Chai
exaly +3 more sources
A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
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The costs and benefits of senotherapeutics for human health
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
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Impact of senolytic treatment on immunity, aging, and disease
Frontiers in Aging, 2023 Cellular senescence has been implicated in the pathophysiology of many age-related diseases. However, it also plays an important protective role in the context of tumor suppression and wound healing.
Erica C. Lorenzo +4 more
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Senolytics as drugs or fashionable dietary supplements [PDF]
Farmacja Polska, 2021 : Senolytics are a group of medicinal substances that selectively remove the so-called aging cells. The available theories indicate that these cells are resistant to apoptosis and accumulate at the causal sites of many chronic disorders and diseases, are
Małgorzata Starek +2 more
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Aging Medicine, 2023 Objective Cell growth involves cell division. This stops after reaching a certain limit. Some cells become inactive and unable to undergo apoptosis (programmed cell death).
Norbert Nwankwo, Ignatius Okafor
doaj +1 more source
Nature Communications, 2020 Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity.
Yonghan He +21 more
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Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products
Biomolecules, 2021 Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological ...
Oscar Salvador Barrera-Vázquez +2 more
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