Results 1 to 10 of about 6,461 (225)
Discovery of senolytics using machine learning
Nature Communications, 2023 Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer Barreto +2 more
exaly +7 more sources
Senolytics and senostatics as adjuvant tumour therapy [PDF]
EBioMedicine, 2019 Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and
Susan Short +3 more
doaj +4 more sources
Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
doaj +6 more sources
The Role of Senolytics in Osteoporosis [PDF]
BiomoleculesCellular senescence is a fundamental contributor to numerous dysfunctions and degenerative diseases, including osteoporosis. In genetically modified and preclinical animal models, therapeutic strategies targeting persistent senescent cells have been ...
Erman Chen +3 more
doaj +2 more sources
Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry [PDF]
Cells, 2022 Cellular senescence is a hallmark of aging and a promising target for therapeutic approaches. The identification of senescent cells requires multiple biomarkers and complex experimental procedures, resulting in increased variability and reduced ...
Marco Malavolta +16 more
doaj +3 more sources
Frontiers in Cell and Developmental Biology, 2022 Senolytics are a class of drugs that selectively eliminate senescent cells and ameliorate senescence-associated disease. Studies have demonstrated the accumulation of senescent disc cells and the production of senescence-associated secretory phenotype ...
Bolin Chen +9 more
doaj +1 more source
The costs and benefits of senotherapeutics for human health
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
doaj +1 more source
Impact of senolytic treatment on immunity, aging, and disease
Frontiers in Aging, 2023 Cellular senescence has been implicated in the pathophysiology of many age-related diseases. However, it also plays an important protective role in the context of tumor suppression and wound healing.
Erica C. Lorenzo +4 more
doaj +1 more source
Senolytics as drugs or fashionable dietary supplements [PDF]
Farmacja Polska, 2021 : Senolytics are a group of medicinal substances that selectively remove the so-called aging cells. The available theories indicate that these cells are resistant to apoptosis and accumulate at the causal sites of many chronic disorders and diseases, are
Małgorzata Starek +2 more
doaj +1 more source
A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
doaj +1 more source