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Immunosenescence and lymphomagenesis [PDF]
Immunity & Ageing, 2018 One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective ...
Salvatrice Mancuso +5 more
doaj +4 more sources
Frontiers in Immunology, 2019 Aging is accompanied by remodeling of the immune system. With time, this leads to a decline in immune efficacy, resulting in increased vulnerability to infectious diseases, diminished responses to vaccination, and a susceptibility to age-related ...
Calogero Caruso +2 more
exaly +3 more sources
Immunosenescence in Caenorhabditis elegans
Immunity & Ageing, 2022 Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity ...
Sieun S. Kim +2 more
doaj +3 more sources
Regulatory RNAs in immunosenescence
Immunity, Inflammation and DiseaseBackground Immunosenescence is a multifactorial stress response to different intrinsic and extrinsic insults that cause immune deterioration and is accompanied by genomic or epigenomic perturbations.
Atefe Ghamar Talepoor +1 more
doaj +3 more sources
Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation
Biomolecules, 2023 Quorum-sensing peptides (QSPs) are bacterial peptides traditionally considered only as inter-bacterial communication molecules. Recently, their involvement in microbiome–host interactions influencing host diseases such as cancer and sarcopenia were ...
Anton De Spiegeleer +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex of an individual, ranging from asymptomatic to lethal.
Mattia Emanuela Ligotti +8 more
doaj +1 more source
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells
Immunity & Ageing, 2022 Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama +5 more
doaj +1 more source
Immunosenescence and cancer [PDF]
Critical Reviews in Oncology/Hematology, 2010 Age is a major risk factor for many cancers. Although this is usually viewed in the context of the cell biology, we argue here that age-associated changes to immunity may also contribute to the age-associated increasing incidence of most cancers. This is because cancers are immunogenic (at least initially), and the immune system can and does protect ...
Graham, Pawelec +2 more
openaire +2 more sources
Immunosenescence of ageing [PDF]
The Journal of Pathology, 2007 AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function.
A L, Gruver, L L, Hudson, G D, Sempowski
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Mechanisms of immunosenescence [PDF]
Immunity & Ageing, 2009 On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B immunosenescence are summarized. In the elderly, many alterations of both innate and acquired immunity have been described.
CARUSO, Calogero +6 more
openaire +5 more sources