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Immunosenescence and lymphomagenesis [PDF]
Immunity & Ageing, 2018 One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective ...
Salvatrice Mancuso +5 more
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Immunosenescence: molecular mechanisms and diseases
Signal Transduction and Targeted Therapy, 2023 Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence).
Quan Cheng, Yi Zhang, Xinwei Han
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Immunosenescence in Caenorhabditis elegans
Immunity & Ageing, 2022 Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity ...
Sieun S. Kim +2 more
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Immunosenescence: signaling pathways, diseases and therapeutic targets
Signal Transduction and Targeted TherapyImmunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of ...
Xiangliang Yang
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Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications [PDF]
Translational NeurodegenerationAging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders.
Zhichun Chen +5 more
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The pathophysiological mechanisms of immunosenescence in coronary artery disease [PDF]
Frontiers in Cell and Developmental BiologyCoronary artery disease (CAD) is the most common coronary heart disease, characterized by the accumulation of atherosclerotic plaques in the coronary arteries, which supply oxygen and nutrients to the heart.
Hengjie Bie, Zhengxian Tao
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Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation
Biomolecules, 2023 Quorum-sensing peptides (QSPs) are bacterial peptides traditionally considered only as inter-bacterial communication molecules. Recently, their involvement in microbiome–host interactions influencing host diseases such as cancer and sarcopenia were ...
Anton De Spiegeleer +9 more
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Frontiers in Cell and Developmental Biology, 2021 The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex of an individual, ranging from asymptomatic to lethal.
Mattia Emanuela Ligotti +8 more
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The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells
Immunity & Ageing, 2022 Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama +5 more
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Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis
Frontiers in Immunology, 2022 Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes.
Xuan Lu +5 more
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