Results 1 to 10 of about 20,223 (261)
Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
Rejuvenation Research, 2008 Aging is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed immunosenescence. This process
CANDORE, Giuseppina +8 more
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Archives of Gerontology and Geriatrics, 2001
Aging involves the morphological and functional integrity of all organs, including the cellular and humoral immunological functions. The main alterations can be listed as follows: (i) Thymic involution resulting in the decreased number of lymphoid precursor T- and B-cells.
MALAGUARNERA, Lucia +7 more
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Aging involves the morphological and functional integrity of all organs, including the cellular and humoral immunological functions. The main alterations can be listed as follows: (i) Thymic involution resulting in the decreased number of lymphoid precursor T- and B-cells.
MALAGUARNERA, Lucia +7 more
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Current Opinion in Immunology, 2012
The present review discusses the interplay between HIV infection and other environmental factors (e.g. co-infection with CMV) in the acceleration of the aging process of the immune system, leading to 'immunosenescence.'Basic studies in cell biology demonstrate that replicative senescence is a common pathway of many cell lineages, including those of the
Steven G, Deeks +2 more
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The present review discusses the interplay between HIV infection and other environmental factors (e.g. co-infection with CMV) in the acceleration of the aging process of the immune system, leading to 'immunosenescence.'Basic studies in cell biology demonstrate that replicative senescence is a common pathway of many cell lineages, including those of the
Steven G, Deeks +2 more
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Immunoproteasomes and immunosenescence
Ageing Research Reviews, 2003Aging is a complex process which is accompanied with the decline and the reshaping of different functions of the body. In particular the immune system is characterized, during ageing (immunosenescence) by a remodeling of innate immunity (well preserved, up-regulated) and clonotypical immunity (severely altered) and by the occurrence of a chronic ...
Mishto M. +5 more
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Gériatrie et Psychologie Neuropsychiatrie du Viellissement, 2015
Immunosenescence is a progressive deterioration of the immune system with ageing. A multifactorial condition, including multimorbidities and environmental factors in the elderly, increases the frailty risks. Some infection and nutritional factors contribute to the onset of decline of response to infection.
Gilles, Berrut, Laure, de Decker
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Immunosenescence is a progressive deterioration of the immune system with ageing. A multifactorial condition, including multimorbidities and environmental factors in the elderly, increases the frailty risks. Some infection and nutritional factors contribute to the onset of decline of response to infection.
Gilles, Berrut, Laure, de Decker
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Rivista di biologia, 2009
Aging is a post-maturational process, biologically characterized by the progressive failure to maintain or restore the physiologic homeostasis. Such a complex phenomenon is influenced by the interaction among genetic, epigenetic, environmental, behavioral and socio-economic factors and involves the whole body, including immune system.
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Aging is a post-maturational process, biologically characterized by the progressive failure to maintain or restore the physiologic homeostasis. Such a complex phenomenon is influenced by the interaction among genetic, epigenetic, environmental, behavioral and socio-economic factors and involves the whole body, including immune system.
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Biogerontology, 2008
Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune system could protect against tumorigenesis ("immunosurveillance"), and vaccination or other immunomodulatory treatments should be therapeutically beneficial, as has been ...
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Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune system could protect against tumorigenesis ("immunosurveillance"), and vaccination or other immunomodulatory treatments should be therapeutically beneficial, as has been ...
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Immunosenescence and infectious diseases
Microbes and Infection, 2001Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines.
GINALDI, Lia +4 more
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Gerontology, 2009
Recent discoveries of changes in cells of the immune system, particularly lymphocytes, shed new light on the phenomenon of aging in cells generally. In the mouse, data are accumulating on the implications for aging from traffic of those cells, and from effector influences and modulator effects concerning T and B cell suppression and T cell help ...
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Recent discoveries of changes in cells of the immune system, particularly lymphocytes, shed new light on the phenomenon of aging in cells generally. In the mouse, data are accumulating on the implications for aging from traffic of those cells, and from effector influences and modulator effects concerning T and B cell suppression and T cell help ...
openaire +2 more sources
Immunosenescence and aging in HIV
Current Opinion in HIV and AIDS, 2014During this era of unprecedented antiretroviral therapeutic efficacy, there is hope for successfully treated individuals to achieve a longevity approaching that of the general population. However, the recent identification of a higher incidence of cardiovascular, bone, metabolic, neurocognitive and other aging comorbidities is of major concern and may ...
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