Results 41 to 50 of about 20,223 (261)

The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs)

Mediators of Inflammation, 2020
Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing.
Patrizia Cancemi, Anna Aiello, Giulia Accardi, Rosalia Caldarella, Giuseppina Candore, Calogero Caruso, Marcello Ciaccio, Laura Cristaldi, Francesca Di Gaudio, Valentina Siino, Sonya Vasto   +10 more
doaj   +1 more source

Report from the second cytomegalovirus and immunosenescence workshop.

, 2011
The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory frequency, inflation and immunosenescence;
Pawelec, Graham, R Macualay (16139510), van Lier, R, Paul Klenerman, Rafael Solana, Beswick, M, Mason Gavin, Goronzy Joerg, Westendorp Rudi, Maier, Andrea B., Akbar, A, Mason, Gavin, Herndler-Brandstetter Dietmar, Wang, George, A B Maier (13318254), Delphine Sauce, David Melzer, Pachnio, A., Kern, F, Caruso Calogero, J Sinclair (7750493), Caruso, C, Gkrania-Klotsas, Effrossyni, A. B. Maier, A Akbar (12141924), Solana, R., Arne Akbar, Bosch, Jos A, Sansoni, Paolo, Henson, SM, Macallan, D., Moss P., Gkrania-Klotsas, E, Henson, S, Dutta, A, Vescovini Rosanna, Macallan D., Morgan M., Macualay, Richard, Mark Beswick, Maier, AB, Hill A., Nikolich-Zugich, J, Fulop, Tamas, Pachnio, A, Wills, M., D. Macallan, Westendorp, Rudi, Giuseppina Colonna-Romano, Melzer D., J Nikolich-Zugich (16139513), Sinclair, J, Mason G., Pachnio, Annette, A. Hill, C. Franceschi, Klenerman, Paul, Wang, G, Sansoni P., Kern, Florian, A. Akbar, G. Colonna Romano, Goronzy, J., Riddell Natalie, E Gkrania-Klotsas (16139495), Griffiths, SJ, Solana Rafael, Graham Pawelec, Bosch Jos A, P. Trzonkowski, P Trzonkowski (16139528), Hill, A., Morgan, Matthew, D Sauce (16139522), Mason, G., Franceschi, C, Riddell, N., D. Melzer, Tamas Fulop, Melzer, D, Wills, Mark, G Colonna-Romano (16139489), Sinclair J., Rene van Lier, Henson, Sian M., CARUSO, Calogero, Dutta, Ambarish, Nikolich-Zugich, J., Sauce, D., S. Henson, Hill, Ann, Caruso, C., Pawelec G., Florian Kern, Kern Florian, Riddell, Natalie, Wills, M, D Melzer (14728009), Gkrania Klotsas, E, Fulop, T., Klenerman, P., J. Goronzy, Trzonkowski Piotr, Jan Strindhall, J. Strindhall, Fulop Tamas, Sansoni, P, Nikolich-Zugich Janko, Janko Nikolich-Zugich, Herndler-Brandstetter, D, Herndler Brandstetter D., Goronzy, Joerg, Colonna-Romano Giuseppina, Akbar, Arne, N. Riddell, Sauce, D, Piotr Trzonkowski, R. Westendorp, Bosch, JA, Jos A Bosch, T Fulop (16139363), Derek Macallan, M. Wills, Griffiths, S.J., R. van Lier, Roberts R., M Beswick (16139483), Melzer, David, Fulop T., Richard Macaulay, Ryan Roberts, Griffiths, Stephen J, C Caruso (16139357), Wang George, van Lier R., Macualay, R, Franceschi, Claudio, P Moss (7787393), Macaulay, R, George Wang, Akbar Arne, J A Bosch (16139486), M. Morgan, Moss Paul, Solana R., Florian Kern (4461943), Gkrania-Klotsas, E., Westendorp R., Trzonkowski, P, J Goronzy (16139498), Rudi Westendorp, Klenerman P., F. Kern, van Lier Rene, Natalie Riddell, P. Moss, Caruso C., Pawelec, G, Strindhall J., R van Lier (16139531), P. Klenerman, Sauce D., Macaulay, Richard, Gkrania Klotsas E., R Vescovini (16139534), Nikolich Zugich, J, Stephen J Griffiths, Akbar, A., Strindhall, J, Sauce, Delphine, Beswick, Mark, Annette Pachnio, Maier, Andrea, Colonna-Romano, Giuseppina, Griffiths Stephen J, N Riddell (16139516), J. Nikolich Zugich, Dutta A., Nikolich-Zugich, Janko, G. Mason, Nikolich Zugich J., Moss, Paul; id_orcid, Macaulay Richard, Roberts, R., M Wills (13757002), Wills M., Franceschi Claudio, Strindhall, Jan, Akbar A., Kern, F., Riddell N., Effrossyni Gkrania-Klotsas, Dutta Ambarish, Pawelec, G., Henson S., A. Pachnio, Colonna-Romano, G., D Macallan (16139381), Joerg Goronzy, Melzer David, M. Beswick, Goronzy, G, Gavin Mason, Colonna Romano G., Sansoni, P., R Roberts (7710605), Goronzy, J, Moss, P, A Pachnio (1928), Klenerman Paul, COLONNA ROMANO, Giuseppina, Morgan Matthew, Vescovini, Rosanna, Melzer, D., T. Fulop, Klenerman, P, Vescovini R., P Sansoni (16139519), D Herndler-Brandstetter (16139507), Sinclair, John, Hill, A, Bosch J. A., P Klenerman (14557544), G Wang (7291427), Pachnio A., van Lier, Rene, Lier, R. van, John Sinclair, Rosanna Vescovini, Macallan, D, Roberts Ryan, Bosch, Jos A., Henson Sian M, Maier A. B., Sinclair John, Griffiths, Stephen J., Paul Moss, Maier, Andrea B, Maier Andrea B, Macallan, Derek, Gkrania-Klotsas Effrossyni, Macaulay, R., Vescovini, R, Morgan, M., Hill Ann, Maier, A.B., Sinclair, J., Pachnio Annette, Paolo Sansoni, Riddell, N, Beswick Mark, Trzonkowski P., Kern F., G. Wang, A Hill (7707728), Herndler-Brandstetter, Dietmar, R Solana (16139525), Griffiths, Stephen, Vescovini, R., Westendorp, R., C Franceschi (16139492), G Mason (15968855), J. Sinclair, Matthew Morgan, A. Dutta, Wills Mark, Moss, Paul, Sian M Henson, Bosch, Jos, Beswick, M., Mason, G, Sauce Delphine, G. Pawelec, Franceschi, C., S. J. Griffiths, R. Roberts, D. Sauce, Goronzy J., Wills1, M, Maier, Andrea B.; id_orcid, Henson, S.M., Moss, P., Strindhall Jan, Trzonkowski, P., Fulop, T, Macualay R., Westendorp, R, R. Macualay, Solana, R, Trzonkowski, Piotr, Ambarish Dutta, Jos Bosch, Mark Wills, Bosch, J.A., Henson, Sian, Dietmar Herndler-Brandstetter, Ann Hill, C. Caruso, Dutta, A., Beswick M., Andrea B Maier, Sansoni Paolo, Herndler Brandstetter, D, G Pawelec (16139351), Calogero Caruso, M Morgan (7738241), Pawelec Graham, Dietmar Herndler-br, Wang G., A Dutta (11812487), E. Gkrania Klotsas, Herndler-Brandstetter, D., Wang, G., Roberts, Ryan, J. A. Bosch, D. Herndler Brandstetter, J Strindhall (16139387), Macallan Derek, S J Griffiths (16139501), Griffiths S. J., R. Solana, Solana, Rafael, S Henson (16139504), Roberts, R, Colonna-Romano, G, Claudio Franceschi, Strindhall, J., Morgan, M, R Westendorp (16139537)   +328 more
core   +1 more source

An omic-based Drug Repurposing approach to modulate Immunosenescence and Inflammaging

, 2023
reservedImmunosenescence is the gradual decline of the immune system in older people characterized by a reduced response to neo-antigens, vaccines and pathogens, due to an increased dysregulation of the innate and adaptive immune system. Key hallmarks of
RAGOGNA, ALICE
core  

Immunosenescence and Cytomegalovirus: where do we stand after a decade?

, 2010
Since Looney at al. published their seminal paper a decade ago it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated increasing prevalence of infection ...
Grubeck-Loebenstein, B, Pawelec, Graham, Sven D Koch, Pawelec, G, Maier, Andrea B., Akbar, A, S D Koch (16139375), Beverly, P, Strindhall, J, A B Maier (13318254), Jahn, Gerhard, Kern, F, Samson, S, Griffiths, Paul, Caruso Calogero, K Hamprecht (16139369), Beatrix Grubeck-Loebenstein, Caruso, C, Samson, Sandrine, Moss, Paul; id_orcid, A Akbar (12141924), M Wills (13757002), A Larbi (16139378), Arne Akbar, Strindhall, Jan, Tamas Fülöp, Fülöp Tamas, Willis, Mark, Trannoy, Emanuelle, E Derhovanessian (16139360), D Macallan (16139381), Maier, AB, Akbar,A, Wills, M., Koch Sven D, Moss, P, Larbi,A, Derhovanessian, Evelyna, Trannoy Emanuelle, G Jahn (16139372), Macallan,D, Derhovanessian, E, Klaus Hamprecht, Kern, Florian, Hamprecht Klaus, Beverley,P, Trannoy, E, Larbi Anis, Jahn, G, Samson Sandrine, Graham Pawelec, Macallan, D, Hamprecht,K, Moss,P, Strindhall, Jan,, Beverley, P, Griffiths Paul, Hamprecht, K, Larbi, A, Paul Moss, Maier, Andrea B, Wills, Mark, Maier Andrea B, Macallan, Derek, Grubeck-Loebenstein, Beatrix, Sandrine Samson, Emanuelle Trannoy, Peter Beverley, Kern,F, Jahn Gerhard, Anis Larbi, P Beverley (16139354), Florian Kern, Kern Florian, Gerhard Jahn, Wills, M, Fülöp, Tamas, Koch, SD, Wills Mark, Moss, Paul, Beverley, Peter, Jan Strindhall, Derhovanessian Evelyna, Grubeck-Loebenstein Beatrix, Maier, Andrea B.; id_orcid, Koch, Sven D., Akbar, Arne, Strindhall Jan, S Samson (16139384), T Fulop (16139363), Derek Macallan, Fülöp, T, Mark Wills, B Grubeck-Loebenstein (16139366), P Griffiths (7757690), Evelyna Derhovanessian, Koch, Sven D, Grubeck Loebenstein, B, C Caruso (16139357), Andrea B Maier, E Trannoy (16139390), G Pawelec (16139351), P Moss (7787393), Larbi, Anis, Calogero Caruso, Pawelec Graham, Akbar Arne, Beverley Peter, Paul Griffiths, Moss Paul, Florian Kern (4461943), J Strindhall (16139387), Griffiths, P, Macallan Derek, Caruso, Calogero, Hamprecht, Klaus   +115 more
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Social environment as a modulator of immunosenescence

, 2022
Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer.
Ceprián, Noemí, Félix, Judith, M. González-Sánchez, I. Martínez de Toda, Díaz del Cerro, Estefanía, J. Félix, M. De la Fuente, González Sánchez, M., Martínez de Toda Cabeza, Irene, Fuente del Rey, Mónica de la, A. Garrido, Garrido Tarrio, Antonio, E. Díaz del Cerro, N. Ceprián   +13 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Immunosenescence and CoQ10

, 2020
The decline of the immune system associated to aging is becoming a global issue nowadays due to the increase of lifespan. Immunosenescence is the deteriorated adaptative capacity of the immune system leading to increase in morbidity and mortality in ...
López-Lluch, Guillermo, Guillermo López-Lluch, Meza-Torres, Catherine, Juan Diego Hernández-Camacho, Catherine Meza-Torres, Hernández-Camacho, Juan Diego   +5 more
core   +1 more source

The Impact of Immunosenescence on Pulmonary Disease [PDF]

, 2015
The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred.
Michelle A. Murray, Murray, Michelle A., Chotirmall, Sanjay Haresh, Sanjay H. Chotirmall   +3 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source