Results 51 to 60 of about 5,611 (223)
Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini +9 more
wiley +1 more source
Table_2_Radiation therapy induces immunosenescence mediated by p90RSK.xlsx
, 2022 Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529) +24 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal +12 more
wiley +1 more source
Immunity & AgeingAging is frequently characterized by an inadequate primary vaccine response, likely due to immunosenescence and inflamm-aging, a low-level, chronic inflammatory state.
Anna Aiello +10 more
doaj +1 more source
Investigating population-level immunosenescence: From bench to bedside
Frontiers in Immunology, 2022 The immune response is remodeled with aging in a process called immunosenescence. Some immunologists conceive immunosenescence as an adaptation of immunity to the aged immune-environment rather than a merely collapsed reactivity of immune cells against ...
Lucas Leite Cunha +4 more
doaj +1 more source
Robustness and Fragility in Immunosenescence
PLoS Computational Biology, 2005 We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associated with disease severity, as measured by the total ...
Sean P. Stromberg, Jean M. Carlson
openaire +5 more sources
COPD as a Disease of Immunosenescence [PDF]
Yonsei Medical Journal, 2019 Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs in many ways, and COPD has been viewed as a disease of accelerated premature aging of the lungs.
Won-Kyung Cho +2 more
openaire +3 more sources
Immunosenescence in HIV infection [PDF]
, 2016 Immunosenescence is the progressive loss of immune tissue that result from (i) functional, (ii) clonal or (iii) systemic changes to the cells or tissue that make up the immune system.
Glenn, Wong Choon Lim +1 more
core +1 more source
Table_4_Radiation therapy induces immunosenescence mediated by p90RSK.XLSX
, 2022 Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529) +24 more
core +1 more source
Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source