Results 51 to 60 of about 20,223 (261)

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review

Journal of Cachexia, Sarcopenia and Muscle
Background Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited ...
Petar Naumovski, Bart De Spiegeleer, Aster Wakjira, Christophe Van De Wiele, Vincent Mouly, Katarzyna Goljanek‐Whysall, Kauê Santana daCosta, Ewerton Cristhian Lima deOliveira, Evelien Wynendaele, Anton De Spiegeleer   +9 more
doaj   +1 more source

Global research trends of immunosenescence: A bibliometric study

Heliyon, 2023
Background: Immunosenescence, an age-related deficit in immunity, associated with multiple disorders and making the successful aging a challenge. Although nearly 4000 articles have been published, only few review articles have summarized the research ...
Hongbo Chen, Yiwei Luo, Xiaohong Zhang, Ruzhen Luo, Yuhong Bian, Yunlong Hou, Yanhui Liu   +6 more
doaj   +1 more source

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways. [PDF]

Aging Cell
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Li J, Zhang Y, Yu D, Li J, Chen K, Chu L.   +5 more
europepmc   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Diet and Immunosenescence

, 2013
Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting of several modifications that increase morbidity and mortality in elderly. Environment, genetic background,
Calogero Caruso, CARUSO, Calogero, Giuseppina Candore, CANDORE, Giuseppina, Carmela Rita Balistreri, ACCARDI, Giulia, BALISTRERI, Carmela Rita, Giulia Accardi   +7 more
core   +1 more source

Investigating population-level immunosenescence: From bench to bedside

Frontiers in Immunology, 2022
The immune response is remodeled with aging in a process called immunosenescence. Some immunologists conceive immunosenescence as an adaptation of immunity to the aged immune-environment rather than a merely collapsed reactivity of immune cells against ...
Lucas Leite Cunha, Lucas Leite Cunha, Victor Alexandre dos Santos Valsecchi, Victor Alexandre dos Santos Valsecchi, Laura Sterian Ward   +4 more
doaj   +1 more source

Cap‐oPMN: Oral Inflammatory Load Quantification Using Capillary Microfluidics and Automated Image Processing

Advanced Materials Technologies, EarlyView.
ABSTRACT Quantifying oral polymorphonuclear neutrophils (oPMNs) is a clinically validated approach for assessing periodontal inflammation. However, current methods, such as manual hemocytometry and flow cytometry, are time‐consuming (>3 h), require invasive sampling, and depend on staining and complex instrumentation, making them unsuitable for point ...
Mohsen Hassani, Azam Zare, Fatemeh Soheili, S. M. Mahdi H. Daneshvar, Mahdi Amrollahi Biouki, Yasaman Tahernezhad, Chunxiang Sun, Michael Glogauer, Ebrahim Ghafar‐Zadeh, Amir Sanati‐Nezhad   +9 more
wiley   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Nutrition, diet and immunosenescence

, 2014
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Simon R. Carding, Carding, Simon, Clements, Sarah J., Carding, Simon R., Maijó, Mònica, Mònica Maijó, Sarah J. Clements, Kamal Ivory, Ivory, Kamal, Claudio Nicoletti, Nicoletti, Claudio   +10 more
core   +1 more source

Does chronic caregiving stress accelerate T cell immunosenescence? [PDF]

, 2018
First paragraph: It is now well understood that the human immune system undergoes considerable changes, termed immunosenescence, as part of the ageing process, resulting in an increased rate of infections and inflammation.
Whittaker, Anna C.; id_orcid, Whittaker, Anna C   +1 more
core   +1 more source