Results 31 to 40 of about 5,611 (223)

The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

Mediators of Inflammation, 2010
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune ...
Carmela Rita Balistreri, Calogero Caruso, Giuseppina Candore   +2 more
doaj   +1 more source

Aging-associated immune system changes in multiple myeloma: The dark side of the moon.

Cancer Treatment and Research Communications, 2021
Multiple myeloma (MM) is a disease of the elderly. Changes that occur in the immune system with aging, also known as immunosenescence, have been associated with decreased tumor immunosurveillance and are thought to contribute to the development of MM and
Alissa Visram, Taxiarchis V. Kourelis
doaj   +1 more source

The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs)

Mediators of Inflammation, 2020
Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing.
Patrizia Cancemi, Anna Aiello, Giulia Accardi, Rosalia Caldarella, Giuseppina Candore, Calogero Caruso, Marcello Ciaccio, Laura Cristaldi, Francesca Di Gaudio, Valentina Siino, Sonya Vasto   +10 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

An omic-based Drug Repurposing approach to modulate Immunosenescence and Inflammaging

, 2023
reservedImmunosenescence is the gradual decline of the immune system in older people characterized by a reduced response to neo-antigens, vaccines and pathogens, due to an increased dysregulation of the innate and adaptive immune system. Key hallmarks of
RAGOGNA, ALICE
core  

Social environment as a modulator of immunosenescence

, 2022
Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer.
Ceprián, Noemí, Félix, Judith, M. González-Sánchez, I. Martínez de Toda, Díaz del Cerro, Estefanía, J. Félix, M. De la Fuente, González Sánchez, M., Martínez de Toda Cabeza, Irene, Fuente del Rey, Mónica de la, A. Garrido, Garrido Tarrio, Antonio, E. Díaz del Cerro, N. Ceprián   +13 more
core   +1 more source

Radiation therapy induces immunosenescence mediated by p90RSK [PDF]

, 2022
Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Le, Nhat-Tu, Yeung, Sai-Ching J., Samanthapudi, Venkata S. K., Burks, Jared K., Palaskas, Nicolas L., Lin, Steven H., Lee, Ling-Ling, Burks, Jared K, Liao, Zhongxing, Cooke, John P., Schadler, Keri L, Cheng, Haizi, Deswal, Anita, Abe, Jun-ichi, Samanthapudi, Venkata S K, Yeung, Sai-Ching J, Herrmann, Joerg, Ko, Kyung Ae, Palaskas, Nicolas L, Yusuf, Syed Wamique, Yoshimoto, Momoko, Xu, Xiaolei, Nurieva, Roza, Kotla, Sivareddy, Cooke, John P, Imanishi, Masaki, Reyes-Gibby, Cielito, Lin, Steven H, Schadler, Keri L., Amir, El-ad David, Kobayashi, Michihiro, Chini, Eduardo   +31 more
core   +1 more source

A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse

Experimental Gerontology, 2023
Senescent cells were recently shown to play a role in aging-related malfunctions and pathologies. This consensus has been facilitated by evidence from senolytic model mice capable of eliminating senescent cells in tissues using well-characterized ...
Yuma Sugiyama, Tanenobu Harada, Yuka Kamei, Tomoharu Yasuda, Tomoji Mashimo, Akihiko Nishikimi, Mitsuo Maruyama   +6 more
doaj   +1 more source

The Impact of Immunosenescence on Pulmonary Disease [PDF]

, 2015
The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred.
Michelle A. Murray, Murray, Michelle A., Chotirmall, Sanjay Haresh, Sanjay H. Chotirmall   +3 more
core   +1 more source

Immunosenescence and CoQ10

, 2020
The decline of the immune system associated to aging is becoming a global issue nowadays due to the increase of lifespan. Immunosenescence is the deteriorated adaptative capacity of the immune system leading to increase in morbidity and mortality in ...
López-Lluch, Guillermo, Guillermo López-Lluch, Meza-Torres, Catherine, Juan Diego Hernández-Camacho, Catherine Meza-Torres, Hernández-Camacho, Juan Diego   +5 more
core   +1 more source