Results 11 to 20 of about 20,223 (261)

Immunosenescence and lymphomagenesis [PDF]

Immunity & Ageing, 2018
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective ...
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa   +5 more
doaj   +6 more sources

Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis [PDF]

Frontiers in Immunology, 2022
Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes.
Yuan-Qiang Lu, Lu Yuan-Qiang
exaly   +4 more sources

Regulatory RNAs in immunosenescence

Immunity, Inflammation and Disease
Background Immunosenescence is a multifactorial stress response to different intrinsic and extrinsic insults that cause immune deterioration and is accompanied by genomic or epigenomic perturbations.
Atefe Ghamar Talepoor, Mehrnoosh Doroudchi   +1 more
doaj   +4 more sources

Immunosenescence in Caenorhabditis elegans

Immunity & Ageing, 2022
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity ...
Sieun S. Kim, Jooyeon Sohn, Seung-Jae V. Lee   +2 more
doaj   +2 more sources

Mechanisms of immunosenescence [PDF]

Immunity & Ageing, 2009
On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B immunosenescence are summarized. In the elderly, many alterations of both innate and acquired immunity have been described.
CARUSO, Calogero, BUFFA, Silvio, CANDORE, Giuseppina, COLONNA ROMANO, Giuseppina, DUNN WALTERS, D, KIPLING, D, PAWALEC, G.   +6 more
openaire   +7 more sources

Targeting immunosenescence for improved tumor immunotherapy

MedComm
Tumor immunotherapy has significantly transformed the field of oncology over the past decade. An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME).
Zaoqu Liu, Lulu Zuo, Zhaokai Zhou, Shutong Liu, Yuhao Ba, Anning Zuo, Yuqing Ren, Chuhan Zhang, Yukang Chen, Hongxuan Ma, Yudi Xu, Peng Luo, Quan Cheng, Hui Xu, Yuyuan Zhang, Siyuan Weng, Xinwei Han   +16 more
doaj   +2 more sources

Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions [PDF]

BMC Medicine
Immunosenescence, the age-related decline in immune function, plays a crucial role in the pathogenesis and progression of lung diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary fibrosis, asthma, and respiratory tract ...
Yin Zhang, Xianzhe Yu, Ping Li, Yaobin Ouyang, Lingling Zhu, Fengming Luo   +5 more
doaj   +2 more sources

CMV and Immunosenescence: from basics to clinics

Immunity & Ageing, 2012
Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people.
Solana Rafael, Tarazona Raquel, Aiello Allison E, Akbar Arne N, Appay Victor, Beswick Mark, Bosch Jos A, Campos Carmen, Cantisán Sara, Cicin-Sain Luka, Derhovanessian Evelyna, Ferrando-Martínez Sara, Frasca Daniela, Fulöp Tamas, Govind Sheila, Grubeck-Loebenstein Beatrix, Hill Ann, Hurme Mikko, Kern Florian, Larbi Anis, López-Botet Miguel, Maier Andrea B, McElhaney Janet E, Moss Paul, Naumova Elissaveta, Nikolich-Zugich Janko, Pera Alejandra, Rector Jerrald L, Riddell Natalie, Sanchez-Correa Beatriz, Sansoni Paolo, Sauce Delphine, van Lier Rene, Wang George C, Wills Mark R, Zieliński Maciej, Pawelec Graham   +36 more
doaj   +4 more sources

Aging and immunosenescence in invertebrates [PDF]

Invertebrate Survival Journal, 2012
Most contemporary research into aging is driven by interest in the human aging process and in interventions that attenuate the normal and pathophysiological effects of aging, or senescence.
D Stanley
doaj   +3 more sources

Immunosenescence

, 2011
INTRODUCTION: Aging involves various complex cellular and molecular changes, including a general decline in immunological functions known as immunosenescence. The clinical consequences of immunosenescence include increased susceptibility to respiratory infections, neoplasias and cardiovascular diseases.
Torres,Karen Cecília de Lima, Pereira,Patrícia de Araújo, Lima,Giselle Sabrina França de, Souza,Bruno Rezende, Miranda,Débora Marques de, Bauer,Moisés Evandro, Romano-Silva,Marco Aurélio   +6 more
core   +4 more sources