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Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications [PDF]
Translational NeurodegenerationAging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders.
Zhichun Chen +5 more
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Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation
Biomolecules, 2023 Quorum-sensing peptides (QSPs) are bacterial peptides traditionally considered only as inter-bacterial communication molecules. Recently, their involvement in microbiome–host interactions influencing host diseases such as cancer and sarcopenia were ...
Anton De Spiegeleer +9 more
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Frontiers in Cell and Developmental Biology, 2021 The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex of an individual, ranging from asymptomatic to lethal.
Mattia Emanuela Ligotti +8 more
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Global research trends of immunosenescence and immunotherapy: A bibliometric study
Human Vaccines & ImmunotherapeuticsImmunosenescence refers to the gradual decline in immune system function with age, increasing susceptibility to infections and cancer in the elderly. The advent of novel immunotherapies has revolutionized the field of cancer treatment.
Wendi Li, Lin Xiao, Haiyang Li, Wei Cui
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The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells
Immunity & Ageing, 2022 Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama +5 more
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Immunosenescence and cancer [PDF]
Critical Reviews in Oncology/Hematology, 2010 Age is a major risk factor for many cancers. Although this is usually viewed in the context of the cell biology, we argue here that age-associated changes to immunity may also contribute to the age-associated increasing incidence of most cancers. This is because cancers are immunogenic (at least initially), and the immune system can and does protect ...
Graham, Pawelec +2 more
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Immunosenescence of ageing [PDF]
The Journal of Pathology, 2007 AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function.
A L, Gruver, L L, Hudson, G D, Sempowski
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Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants
npj Vaccines, 2022 Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and cancers. However, the mechanism by which their cell surface receptors promote their uptake into dendritic cells
Satoki Kitagawa +5 more
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Autoimmune diseases are more common in women: insights into sex and gender differences in autoimmunity [PDF]
Exploration of ImmunologyAutoimmune diseases (ADs) comprise a heterogeneous group of disorders characterised by a breakdown of immune tolerance and chronic immune-mediated tissue damage.
Anna Calabrò +4 more
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Bibliometric and visualization analysis of global research trends on immunosenescence (1970–2021)
Experimental Gerontology, 2023 Background: Immunosenescence, the aging of the immune system, leads to a decline in the body's adaptability to the environment and plays an important role in various diseases. Immunosenescence has been widely studied in recent years. However, to date, no
Yao Tan +7 more
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