Results 1 to 10 of about 14,164 (239)

Inflammaging as a prodrome to Alzheimer's disease [PDF]

Journal of Neuroinflammation, 2008
Recently, the term "inflammaging" was coined by Franceshci and colleagues to characterize a widely accepted paradigm that ageing is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses. Inflammaging differs significantly
Rrapo Elona, Obregon Demian, Nikolic William V, Fernandez Francisco, Giunta Brian, Town Terrence, Tan Jun   +6 more
doaj   +5 more sources

Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions [PDF]

Cells, 2021
The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes ...
Parveen Bazard, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu, Bo Ding   +10 more
doaj   +2 more sources

Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging [PDF]

Immunity & Ageing
Background Healthy aging is increasingly challenged by inflammaging, a chronic, low‑grade inflammatory state primarily exacerbated by gut microbiota dysbiosis and declining immune function.
Sheryl S.L. Tan, Vandana Garg, Abhijeet Dhiman, Nitu Bansal, Patricia Conway   +4 more
doaj   +2 more sources

Inflammaging Beyond Biomarkers: Molecular Mechanisms and Therapeutic Opportunities [PDF]

Current Issues in Molecular Biology
Inflammaging is defined as chronic low-grade inflammation associated with aging and is increasingly recognized as a dynamic and mechanistically driven biological process rather than a state adequately described by circulating biomarkers alone ...
Amelia Tero-Vescan, Ruxandra Ștefănescu, Amalia Pușcaș, Mădălina Buț, Bianca-Eugenia Ősz, Mark Slevin   +5 more
doaj   +2 more sources

STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

iScience, 2022
Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics ...
Hyunmi Kim, Soo Jung Park, Ilo Jou
doaj   +1 more source

Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness

Frontiers in Immunology, 2022
Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers.
Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Isabella Batten, Isabella Batten, Conor Reddy, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O’Neill, Desmond O’Neill, James Gibney, Sean P. Kennelly, Sean P. Kennelly, Nollaig M. Bourke, Nollaig M. Bourke   +16 more
doaj   +1 more source

INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES

Anti-Aging Eastern Europe, 2022
Ageing is associated with a progressive decline in muscle mass and quality. Inflammaging, chronic low-grade inflammation is a major causative as well as maintenance factor in age-related disorders.
Kshitij Jagtap, Leonardo Santos Hoff, Edoardo Conticini, R. Naveen, Latika Gupta   +4 more
doaj   +1 more source

Adipose tissue aging is regulated by an altered immune system

Frontiers in Immunology, 2023
Adipose tissue is a widely distributed organ that plays a critical role in age-related physiological dysfunctions as an important source of chronic sterile low-grade inflammation. Adipose tissue undergoes diverse changes during aging, including fat depot
Yi-Xiang Zhang, Min-Yi Ou, Zi-Han Yang, Yu Sun, Qing-Feng Li, Shuang-Bai Zhou   +5 more
doaj   +1 more source

Connecting aging biology and inflammation in the omics era

The Journal of Clinical Investigation, 2022
Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.
Keenan A. Walker, Nathan Basisty, David M. Wilson III, Luigi Ferrucci   +3 more
doaj   +1 more source

Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

iScience, 2021
Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin   +12 more
doaj   +1 more source