Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations [PDF]
Frontiers in ImmunologyInflammaging, defined as chronic, low-grade, systemic inflammation that increases with age in the absence of overt infection, is a phenomenon that was first described in 2000 as a member of a growing number of age-related processes that had pleiotropic ...
Ebru Karpuzoglu +2 more
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From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction [PDF]
CellsAging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca +8 more
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Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway [PDF]
Acta Odontologica ScandinavicaBackground: Inflammaging plays a pivotal role in the pathogenesis of multiple age-related diseases, including periodontitis. Advanced glycation end products (AGEs) are known to induce inflammaging and exacerbate periodontitis. However, the mechanisms by
Lin Xiong +7 more
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Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
Frontiers in Immunology, 2019 Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases ...
Freek J. H. Sorgdrager +10 more
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Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle [PDF]
Frontiers in ImmunologyAging is associated with profound alterations in the immune system, characterized by immunosenescence and inflammaging, which together compromise host defense, promote chronic low-grade inflammation, and contribute to the development of age-related ...
Ludmila Müller, Svetlana Di Benedetto
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Quantifying Information Exchange Between Cells in Inflammaging [PDF]
BioengineeringInflammaging is inflammation caused by altered cell–cell communications due to aging which leads to impaired wound healing. In this study, we investigated the underlying dynamics of information exchange between macrophage and fibroblast cells during ...
Israr B. M. Ibrahim, Ramana M. Pidaparti
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
iScience, 2022 Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics ...
Hyunmi Kim, Soo Jung Park, Ilo Jou
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Frontiers in Immunology, 2022 Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers.
Adam H. Dyer +16 more
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INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES
Anti-Aging Eastern Europe, 2022 Ageing is associated with a progressive decline in muscle mass and quality. Inflammaging, chronic low-grade inflammation is a major causative as well as maintenance factor in age-related disorders.
Kshitij Jagtap +4 more
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Adipose tissue aging is regulated by an altered immune system
Frontiers in Immunology, 2023 Adipose tissue is a widely distributed organ that plays a critical role in age-related physiological dysfunctions as an important source of chronic sterile low-grade inflammation. Adipose tissue undergoes diverse changes during aging, including fat depot
Yi-Xiang Zhang +5 more
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