Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging [PDF]
Immunity & AgeingBackground Healthy aging is increasingly challenged by inflammaging, a chronic, low‑grade inflammatory state primarily exacerbated by gut microbiota dysbiosis and declining immune function.
Sheryl S.L. Tan +4 more
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Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations [PDF]
Frontiers in ImmunologyInflammaging, defined as chronic, low-grade, systemic inflammation that increases with age in the absence of overt infection, is a phenomenon that was first described in 2000 as a member of a growing number of age-related processes that had pleiotropic ...
Ebru Karpuzoglu +2 more
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From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction [PDF]
CellsAging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca +8 more
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Inflammaging Beyond Biomarkers: Molecular Mechanisms and Therapeutic Opportunities [PDF]
Current Issues in Molecular BiologyInflammaging is defined as chronic low-grade inflammation associated with aging and is increasingly recognized as a dynamic and mechanistically driven biological process rather than a state adequately described by circulating biomarkers alone ...
Amelia Tero-Vescan +5 more
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
iScience, 2022 Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics ...
Hyunmi Kim, Soo Jung Park, Ilo Jou
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Frontiers in Immunology, 2022 Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers.
Adam H. Dyer +16 more
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INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES
Anti-Aging Eastern Europe, 2022 Ageing is associated with a progressive decline in muscle mass and quality. Inflammaging, chronic low-grade inflammation is a major causative as well as maintenance factor in age-related disorders.
Kshitij Jagtap +4 more
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Adipose tissue aging is regulated by an altered immune system
Frontiers in Immunology, 2023 Adipose tissue is a widely distributed organ that plays a critical role in age-related physiological dysfunctions as an important source of chronic sterile low-grade inflammation. Adipose tissue undergoes diverse changes during aging, including fat depot
Yi-Xiang Zhang +5 more
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Connecting aging biology and inflammation in the omics era
The Journal of Clinical Investigation, 2022 Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.
Keenan A. Walker +3 more
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iScience, 2021 Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang +12 more
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